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BioWorld Science

@BioWorldScience

Essential discovery and preclinical research news to support crucial drug R&D decisions at the earliest stages.

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Joined May 2022
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New obesity classification reveals health risks missed by BMI bioworld.com/articles/735273… #preclinical #research #science #news #Obesity #BMI #WaistCircumference #PreclinicalObesity #ClinicalObesity
New obesity classification reveals health risks missed by BMI

New obesity classification reveals health risks missed by BMI

Body mass index (BMI) has been widely used in medical practice to define obesity, although it may misclassify part of the population because it does not directly reflect excess body fat or its impact...

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SRTD raises €31.5M seed round for disease-specific mRNAs (free w/ registration) #financings #preclinical #research #science #news bioworld.com/articles/735343…
SRTD raises €31.5M seed round for disease-specific mRNAs

SRTD raises €31.5M seed round for disease-specific mRNAs

Messenger RNA specialist SRTD Biotech GmbH has closed a €31.5 million (US$31 million) seed round to fund preclinical development of targeted therapies that express their payloads only within diseased...

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Glioblastoma follows a potentially targetable sequence of states (free w/ registration) bioworld.com/articles/735232… #cancer #preclinical #research #science #news
Glioblastoma follows a potentially targetable sequence of states

Glioblastoma follows a potentially targetable sequence of states

Glioblastoma may be more organized than previously thought. Despite occurring in different brain regions, or being classified into different tumor subtypes, this aggressive brain cancer has lacked a...

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T-Therapeutics raises $133M for TCR bispecifics in cancer, autoimmune (free w/ registration) bioworld.com/articles/735272… #financing #preclinical #research #science #news
T-Therapeutics raises $133M for TCR bispecifics in cancer, autoimmune

T-Therapeutics raises $133M for TCR bispecifics in cancer, autoimmune

T-Therapeutics Ltd. has raised $133 million in an oversubscribed series B, providing the means to deliver clinical proof of concept for its T-cell receptor-CD3 bispecifics in solid tumors and...

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New steps to improve and advance CAR T-based strategies (free w/ registration) bioworld.com/articles/735128… #preclinical #research #science #news
New steps to improve and advance CAR T-based strategies

New steps to improve and advance CAR T-based strategies

Researchers are taking new steps to improve CAR T-cell therapies by better understanding their behavior and engineering them to overcome some of their limitations, from treatment failure and T-cell...

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Single-cell maps expose hidden routes from DNA to disease (free w/ registration) bioworld.com/articles/735087… #preclinical #research #science #news
Single-cell maps expose hidden routes from DNA to disease

Single-cell maps expose hidden routes from DNA to disease

A person’s DNA sequence is largely the same across cells, but the effects of genetic variation can differ sharply. Three companion Australian single-cell studies reveal disease-linked regulatory...

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Study reveals distinct gene expression profiles in early onset CRC (free w/ registration) bioworld.com/articles/735127… #cancer #preclinical #research #science #news
Study reveals distinct gene expression profiles in early onset CRC

Study reveals distinct gene expression profiles in early onset CRC

A single cell RNA sequencing atlas of colorectal cancers (CRC) from patients ages 29 to 90-plus, has pinpointed age-associated differences in tumor composition and gene expression, creating a...

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#ESGCT2026: AAVs cross tissues and cells tracing toxicity routes (free w/ registration) bioworld.com/articles/735053… #preclinical #research #science #news
ESGCT 2026: AAVs cross tissues and cells tracing toxicity routes

ESGCT 2026: AAVs cross tissues and cells tracing toxicity routes

Gene and cell therapies based on viral vectors such as adeno-associated viruses (AAVs) have come under scrutiny following the recent deaths of several patients in clinical trials. Although some...

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#ESGCT2026: Beyond viruses for nucleic acid delivery (free w/ registration) bioworld.com/articles/735036… #preclinical #research #science #news
ESGCT 2026: Beyond viruses for nucleic acid delivery

ESGCT 2026: Beyond viruses for nucleic acid delivery

Nonviral gene delivery is expanding beyond traditional approaches, with researchers exploring modified DNA, transposons, circular RNA and polymer-based nanoparticles to achieve durable expression,...

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At #ESGCT2026, lessons for gene therapy from antisense, vaccines (free w/ registration) bioworld.com/articles/734981… #preclinical #research #science #news
At ESGCT 2026, lessons for gene therapy from antisense, vaccines

At ESGCT 2026, lessons for gene therapy from antisense, vaccines

A perhaps unexpected theme of the first day of the European Society for Cell and Gene Therapy’s 2026 annual congress is how those in the cell and gene therapy field can profit from progress in...

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Asymmetric synthesis drives chiral drug discovery (free w/ registration) bioworld.com/articles/734925… #preclinical #research #science #news
Asymmetric synthesis drives chiral drug discovery

Asymmetric synthesis drives chiral drug discovery

The 2026 Nobel Prize in Chemistry was awarded to Henri Kagan and Kenso Soai for their discoveries in asymmetric organic synthesis, a set of reactions that makes it possible to preferentially obtain...

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#ESMO26: Applying AI across tumor types (free w/ registration) bioworld.com/articles/734908… #cancer #preclinical #research #science #news
ESMO 2026: Applying AI across tumor types

ESMO 2026: Applying AI across tumor types

Tumor-agnostic biology as a field is well-suited to AI in principle. It has simply massive amounts of highly complex data spanning multiple individual fields – a great place to spot connections that...

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Redox-based electrocatalyst controls blood sugar (free w/ registration) bioworld.com/articles/734977… #endocrine #metabolic #preclinical #research #science #news
Redox-based electrocatalyst controls blood sugar

Redox-based electrocatalyst controls blood sugar

Researchers at ETH Zürich have developed an implant that catalyzed the oxidation of glucose to gluconate, a metabolite that is easily excreted by the kidneys. In mice, the device could rapidly bring...

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The first spark of ANCA kidney injury comes into focus (free w/ registration) bioworld.com/articles/734870… #nephrology #preclinical #research #science #news
The first spark of ANCA kidney injury comes into focus

The first spark of ANCA kidney injury comes into focus

Researchers from the University of Osaka have found that, long before antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis progresses to overt kidney injury, stressed renal...

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Alzheimer’s blood tests mean earlier diagnosis, new type of patient bioworld.com/articles/734888… #biomarkers #neurology #diagnostics #research @WorldDementia
Alzheimer’s blood tests mean earlier diagnosis, new type of patient

Alzheimer’s blood tests mean earlier diagnosis, new type of patient

New blood-based biomarker tests that detect Alzheimer’s before symptoms appear are poised to transform the clinical landscape by catching the disease when controlling for risk factors is known to...

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#UEGWeek: Early antibiotic exposure linked to IBS in adulthood (free w/ registration) bioworld.com/articles/734808… #gastrointestinal #preclinical #research #science #news
Early antibiotic exposure linked to IBS in adulthood

Early antibiotic exposure linked to IBS in adulthood

At the United European Gastroenterology Week (UEGW) 2026 annual conference being held in Barcelona Oct. 17-20, a team of researchers from the Karolinska Institutet, the Sahlgrenska University...

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Duke takes digital twins from snapshots to living models (free w/ registration) bioworld.com/articles/734757… #preclinical #research #science #news
Duke takes digital twins from snapshots to living models

Duke takes digital twins from snapshots to living models

A decade ago, Amanda Randles and her colleagues could use a supercomputer to simulate only a few heartbeats through a patient’s cardiovascular anatomy. Duke University researchers now believe they...

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Complete genomes reveal hidden somatic mutations (free w/ registration) bioworld.com/articles/734738… #preclinical #research #science #news
Complete genomes reveal hidden somatic mutations

Complete genomes reveal hidden somatic mutations

A consortium funded by the National Institutes of Health (NIH) has unveiled the most comprehensive map of somatic mosaicism to date, uncovering the mutations that arise during development and aging...

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Moderna designs bispecific antibodies against SARS-CoV-2 variants (free w/ registration) bioworld.com/articles/734705… #COVID19 #preclinical #research #science #news
Moderna designs bispecific antibodies against SARS-CoV-2 variants

Moderna designs bispecific antibodies against SARS-CoV-2 variants

Scientists at Moderna Inc. are seeking a solution to the rapid emergence of viral variants that escape treatments. Many monoclonal antibodies (mAbs) initially work well against a single target but...

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γδ T cells expose hidden immune vulnerability in small-cell lung cancer (free w/ registration) bioworld.com/articles/734675… #cancer #preclinical #research #science #news
γδ T cells expose hidden immune vulnerability in small-cell lung cancer

γδ T cells expose hidden immune vulnerability in small-cell lung cancer

Researchers have identified gamma delta (γδ) T cells as potent killers of small-cell lung cancer (SCLC), with their genetic signature potentially revealing patients who could benefit from immunothe...

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