Cell Reprogramming in Hematopoiesis and Immunity. @LuWcmm @Lund_Stem @lunduniversity. Tweets by Filipe Pereira (signed FP) and Malavika Nair (for CFP lab).
Lund, Sverige
Joined June 2016
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1/3 Following our recent Immunity publication, we're excited to announce a new Swedish Research Council grant: “Engineering Immunogenic Tertiary Lymphoid Structures by Tumour-to-Dendritic Cell Reprogramming.” This project will take our discoveries one step further.🙌
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2/3 We will identify the molecular drivers of imgTLS formation and develop an imgTLS-inducing gene therapy capable of combining dendritic cell-driven immune activation with the generation of these specialized immune hubs.
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3/3 Ultimately, we aim to determine whether induced imgTLSs can transform the treatment of refractory cancers. We thank our collaborators Dr. Inge Marie Svane and Dr. Göran B. Jönsson, and are grateful to the Swedish Research Council for making this possible. #TLSimmunotherapy
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1) 📢 New study out in @ImmunityCP : We show that tumor-to-cDC1 reprogramming induces tertiary lymphoid structures (TLSs) across cancers. Read it here:sciencedirect.com/science/ar…. A thread 🧵
#TLS #reprogramming #immunotherapy
Graphical abstract by Avesta Rastan.
14) 👥 We are grateful to our collaborators Göran B Jönsson, Anna Darabi and Johan Bengzon, and @AsgardThx for their incredible contributions!
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15) 🙏🏻 A big thank you to all the funding agencies for making this possible: @CancerResearch, @EUeic, @Cancerfonden, @Vetenskapsradet, @vinnovase, @theABTA, Mats Paulsson Foundation, @KAWstiftelsen, LUCC, @fct_pt, and @FEEICOMPETE2030.
Honored to contribute to “Twenty Years of Induced Pluripotent Stem Cells” in @NatureCellBio, a collection marking 20 years since the discovery of iPSCs. I discuss how cellular reprogramming has evolved to show that stable cell identities can be rewritten.🔗shorturl.at/H1mJh
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The transformative concept of cellular reprogramming is now being applied for in vivo cancer immunotherapy. How might the next 20 years expand reprogramming approaches within the tumor microenvironment? Exciting times ahead!
#iPSC #CellularReprogramming #CancerImmunotherapy
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