Cancer Immunometabolism; Professor of Immunology @PittTweet; AD for Basic @UPMCHillmanCC; EiC:Immunology - views my own
Pittsburgh, PA
Joined June 2017
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Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s41586-0…
This trial is of an oncolytic virus that encodes a novel TGFbeta receptor inhibitor that we developed in the lab. Super excited to see it change the lives of cancer patients!
See the preclinical paper here: rupress.org/jem/article/220/…
We're pleased to share that our STEALTH-001 clinical trial abstract was one of just two selected for the inaugural SITC Biotech Innovation Spotlight Award!
Thank you to Dr. Yana Najjar, our investigators, collaborators and patients.
#SITC2026 #CancerImmunotherapy
#SITC26 was a great event!
However, my hot take is we we'll never improve/solve cancer immunotherapy without deep understanding of cancer immunology. We must promote and highlight basic understanding of the cancer:immunity problem without needing to immediately move to therapy.
Had an awesome time presenting our postprandial data on immunology and immunotherapy at #SITC26, and moderating a stellar and entertaining debate on time-of-day and immunotherapy. Tomorrow I'll be at the Prez Sesh discussing two of our 4 SITC Presidential Talks!
Delgoffe Lab retweeted
KaliVir reports preliminary Phase 1/1b STEALTH-001 data at #SITC2026
71% ORR (5/7) in advanced cutaneous cancers
Responses in non-injected lesions suggest potential systemic activity
Read more: bit.ly/4sKNFBC
#VET3TGI #SITC2026
Delgoffe Lab retweeted
Congratulations to Dr John Kirkwood ( @jmkirkwood ) inducted today as a 2026 Fellow of the Academy of Immunology-Oncology @sitcancer for his pioneering research in the field of #melanoma as well as his leadership. @UPMCnews @PittHealthSci
America’s scientific future depends on what Congress does next thehill.com/opinion/congress…
Delgoffe Lab retweeted
How the diet & microbiome may lead to immune adverse effects. Join immunologist, Dr. Abby Overacre (@OveracreLab ) later today at #SITC2026. Session 106d | Mechanisms of irAEs | 1:45-3:25 pm | North Building | 300 Level | Hall A
@UPMCnews @PittHealthSci @PittDeptofMed
Join us at Tom’s Watch Bar on Friday if you’re at #SITC26!
If you’re attending the #SITC2026 conference in Phoenix this week be sure to stop by and meet up with our team of immunologists for a casual get together on Friday, Nov. 6th. Please register using the QR code below! See you there! @gmdelgoffe @UPMCnews @PittHealthSci
Delgoffe Lab retweeted
CRI STARs take the stage at #SITC26 today!
🔹 @j_eyquem (@UCSF): In vivo and Solid Tumor CAR-T Cell Therapies | 3:10 PM
🔹 @gmdelgoffe (@PittTweet): Funding Your Research Through Industry Collaboration | 3:15 PM
Explore the sessions: bit.ly/3UmhtYJ
This is an important issue. Streamlining the bottom 70% instead of 50% removes the grants that actually NEED discussion! A grant that got all 2s needs no discussion; it’s good. But a 2,3,5 (which prob would be discussed at top 50% triage) actually needs expert discussion more.
NIH study sections are in poor shape right now. Reviewing only the top third of preliminary scores lets a single reviewer eliminate a grant with no chance of recovery. This favors conservative, incremental ideas from established PIs and summarily cuts down new entrants at the preliminary stage. Far from “gold standard science,” the process has worsened under this regime even though Congress did not cut the NIH budget. A thorough investigation is needed into the political interference behind these changes and fund allocation. The prior system was imperfect and needed reform, but the outcome from the last 20 months has been wholesale destruction by imbeciles.
What an incredible night! 🌊
Now, how about a bipartisan bill to double (protect?) the @NIH budget? Let's promote and retain our leadership in global science!
More scientists in government! Amazing!
Microbiology PhD wins Congressional seat.
cbsnews.com/atlanta/news/geo…
3
520
Delgoffe Lab retweeted
Microbiology PhD wins Congressional seat.
cbsnews.com/atlanta/news/geo…
Delgoffe Lab retweeted
Jean-Luc Picard remains the single most compelling vision of progressive politics I am familiar with — secular, rational, compassionate, egalitarian; a believer in progress & abundance but also duty, hard work, and a constant battle for self-improvement and improving the world.
Delgoffe Lab retweeted
"It is possible to commit no mistakes and still lose. That is not a weakness. That is life." - Captain Jean-Luc Picard 😭
Delgoffe Lab retweeted
Sorry we’re busy RUNNING flow! Feat our fave @BioLegend antibodies
@ItzDipyaman @IshitaBaral02 @allicafferata @hannahjbum4
