Genes & Development

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also featuring two Review articles on the 3D genome in cancer, and the regulation of noninfectious granulomas. Click here to learn more: ➡️ genesdev.cshlp.org/content/4…

RESEARCH PAPER: Sharp cell type boundaries emerge from coordinated morphogen signaling By Li et al. and Peggy Myung ➡️ genesdev.cshlp.org/content/4… @Yale #morphogen #WNT #Hedgehog #patterning

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: C. elegans CEH-43/DLX drives convergent astrocyte differentiation by sequential control of axon guidance and synaptic gene expression programs By Liu et al. and Shai Shaham ➡️ ow.ly/7SjZ5104IMj @RockefellerUniv #neuron #glia

RESEARCH PAPER: A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer By Masuzawa et al. and Matthew Oser ➡️ genesdev.cshlp.org/content/4… @Oser_Lab @DanaFarber @harvardmed #lungcancer #ubiquitin #transcriptionfactor

RESEARCH PAPER: Decoding anterior–posterior patterning cues into embryo-wide binary fate decisions through recruitment-mediated targeting By Xiao et al. and Zhuo Du ➡️ genesdev.cshlp.org/content/4… #patterning #Wnt #Celegans

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest By Ha et al. and Louis Lefebvre ➡️ ow.ly/iQby5104GhZ @LouisLefebvre42 @UBC @ubclifesciences #3Dgenome #chromatin #imprinting

📽️ G&D Tapes 📽️ G&D Author, Inma Gonzalez, tells us about MAX: a mitotic bookmarking transcription factor that potentiates MYC-driven hyper-transcription and genome reactivation. Learn more here: ➡️ genesdev.cshlp.org/content/4… @pablonavarroLAB @institutpasteur #transcription #MYC

RESEARCH PAPER: Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters By Gonzalez et al. and Pablo Navarro ➡️ genesdev.cshlp.org/content/4… @pablonavarroLAB @institutpasteur #transcription #transcriptionfactor #mitosis #MYC

REVIEW: Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics By Smith et al. and Yu (Sunny) Liu ➡️ genesdev.cshlp.org/content/4… @YuLiu_Sunny @CeiFccc @FoxChaseCancer @FCCCAcademics #cancer #epigenetics #chromatin

🎙️ G&D Voices: Author David Gutmann 🎙️ A longstanding connection to CSHL makes publishing in G&D especially meaningful. Here is why scientists choose G&D to share their research.

RESEARCH PAPER: mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency By Fan et al. and Marikki Laiho ➡️ genesdev.cshlp.org/content/4… @JohnsHopkins #cancer #ribosome #translation #mTOR

RESEARCH COMMUNICATION: Chromosomal requirements for formation of multivalent human nucleoli By Krystyna Giemza, Hazel Mangan, and Brian McStay ➡️ genesdev.cshlp.org/content/4… @Galway_Research #chromosome #nucleolar #ribosome

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Lymphatics-epicardial cross talk via Reelin controls cardiac growth By Zhou et al. and Guillermo Oliver ➡️ ow.ly/olCe51035py @NU_Lymphatics @NUFeinbergMed #lymphatics #cardiac #repair #regeneration

RESEARCH PAPER: Multiple quality control checkpoints safeguard small nuclear RNA biogenesis and prevent assembly of aberrant spliceosomes By Ma et al. and ens Lykke-Andersen ➡️ genesdev.cshlp.org/content/4… @UCSanDiego #RNA #RNAdecay #RNAsplicing

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The hnRNPA1 D262V amyotrophic lateral sclerosis (ALS) mutation is linked to mitochondrial dysfunction By Lee et al. and Donald Rio ➡️ ow.ly/M2oO5102hCe #ALS #mutation #neuron #mitochondria #RNA

📽 G&D Tapes 📽 G&D authors tell us about how MYC-PVT1-derived Firefox and Honeybadger regulate MYC-driven oncogenesis. Learn more in these complementary studies by Anindya Bagchi’s group: ➡️ ow.ly/cgwh5102g73 #cancer #MYC #KRAS #lncRNA

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Initial perturbations triggered by p53 loss in stem cells By Fan et al. and John Abrams ➡️ ow.ly/ss9b5102hwF #cancer #p53 #stemcell

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity By Ashour et al. and Nima Mosammaparast ➡️ ow.ly/hhmQ51012Xt #DNArepair #cancer #chemotherapy

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer By Masuzawa et al. and Matthew Oser ➡️ ow.ly/Sq7451013oy @Oser_Lab #lungcancer #ubiquitin #transcriptionfactor

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Decoding anterior–posterior patterning cues into embryo-wide binary fate decisions through recruitment-mediated targeting By Xiao et al. and Zhuo Du ➡️ ow.ly/SCJk5100YF0 #patterning #Wnt #Celegans