
Medical journalist. Science editor for @POZmagazine, Hep & CancerHealth. Words for @aidsmap, @Slate, @eBARnews. Research beagle adopter. Same handle on Blue.
San Francisco
Joined March 2009
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I have tried very hard to be good faith and admit the problems with this version of transgender healthcare.
But if a study comes out showing the regret rate for adolescents is low? And the supposed advocates of science just throw it out because it says something they don’t wanna hear?
You’re not scientists, you’re hacks.
Just about every single study done in Trans medicine has methodological problems. The double standard is how it only discredits the study when it says what you don’t wanna hear.
What is the point of even having a conversation? Do y’all not see how you’re lining up to spout the same talking points? The psychology of what you’re engaged in is so obvious.
You’re gonna be opposed to minors transitioning no matter what the facts are.
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Amid all the pre-election prognostication & punditry, I don’t recall hearing Mississippi mentioned once as a blue prospect. Just goes to show, you can’t write off the south. (And I hope Florida will shift purple again too, as it was when I was growing up there.)
reuters.com/world/us/democra…
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Running a campaign as an underdog against an entrenched incumbent in a deep red state is hard.
Running a campaign where you are underfunded is even harder.
Running a campaign where you are underfunded because people repeatedly say you have no shot is even harder than that.
Running a campaign as a Black man in a state with decades of seemingly immovable racial polarization is even harder than that.
Running a campaign where history rests heavily on your shoulders — in a state where the last Black U.S. Senator was born a slave, with the specter of segregation, Jim Crow, Emmett Till, Medgar Evers, and countless more looming — is even harder than that.
It takes a fearless candidate, a tireless campaign team, and a perfect storm to get here.
Congratulations to Scott, his family, his team, and to the state of Mississippi on this monumental achievement.
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Liz Highleyman retweeted
This thread is astonishing. The most puzzling aspect yo me is not even the incompetence and paralysis of the autorities but the resignation and fatalism. It feels like reading some chronicle by a medieval peasant ...
Liz Highleyman retweeted
This new tirzepatide study is eye-opening.
120 adults took the drug for 40 weeks, and half of them also lifted weights 3x a week. Both groups lost about 50 lbs.
But when they tested strength, the two groups looked nothing alike.
Here's the breakdown: (1/11)
Liz Highleyman retweeted
This is demonstrably false.
In 40 years, there has not been a single lifestyle intervention that, in trials, worked for long-term weight loss.
GLP-1 users lose weight *and* improve their diet.
You guys had nearly a half-century to come up with something, and you didn't.
Just giving a GLP-1 without lifestyle intervention is not helping the health of a patient. Make #lifestylemedine a regular part of women's healthcare.--Dr. Steve Fleischman at #LM2026.
Liz Highleyman retweeted
Here’s a classic play on government price controls. Trump hatches an MFN scheme that holds pharma to prices paid in a basket of other developed countries in exchange for being let off the hook on tariffs. Pharma then holds back new drugs from European governments to avoid the benchmark and prices them higher in the US to make up for the loss of revenue in those other countries. US pays more, Europe’s lag in new drug adoption worsens. Patients everywhere are treated like pawns.
wsj.com/health/pharma/trumps…
Liz Highleyman retweeted
🔎 Explore the latest evidence & insights on #HIV co-infections.
Discover a range of resources on #IASPlus covering tuberculosis, viral hepatitis, sexually transmitted infections & more.
Access expert perspectives, research findings & recordings from past conferences to inform integrated approaches to HIV prevention, treatment & care:
plus.iasociety.org/search/re…

ALT The image shows a webpage from IAS+ featuring various resources related to AIDS 2026. There are multiple thumbnail images with titles like "Coconut Indaba" and "Mongongo." Each resource has a "View" button. The layout is in a grid format with a red and white color scheme. The top navigation bar includes options like Home, Events, and Newsroom. Filters are available on the left for refining search results.
Liz Highleyman retweeted
Republicans have introduced a federal ‘catch kit’ bill that would require women to sift thru their blood to separate pregnancy remains from “other solid waste,” put it in a “brightly colored” bag labeled “HUMAN FETAL REMAINS,” and bring their doc.
It’s fucking deranged
Liz Highleyman retweeted
I'm increasingly despondent about how binary the AI debate has become in the US. Either you're naively pro-AI, happy to see massive data center build-out and a handful of frontier model companies become central to everything we do online, or you want to pause research, stop the build-out, and discourage people from using AI.
Almost nowhere do I see people talking about the need for decentralized AI. To me, this is the only safe way forward.
There's an underlying truth to both sides of the naive debate.
The pro-AI camp is right that refusing these technologies leaves enormous consumer welfare gains on the table. An individual using an AI agent to interact with companies and governments can stand up for their own interests rather than accept whatever terms or bureaucracy they're offered without a practical means of negotiating. And refusing to advance AI research would have enormous national security and competitiveness consequences as adversaries develop technologies that could exploit our increasingly vulnerable infrastructure.
The anti-AI camp is right that a world where everyone uses the same handful of inference providers for their most intimate affairs rapidly looks like a corporate panopticon. Ask yourself whether you really want every self-driving car to have a corporate kill switch. Sure, we could just regulate and trust giant inference providers, as we've done with Big Tech companies like Google. But the stakes are much higher when these companies sit at the center of virtually all our computing, and increasingly our physical infrastructure. Email and cloud storage were just the beginning.
Both of these positions can be true. And their synthesis points toward a third way.
We should be supercharging AI development and adoption while encouraging sovereign AI: systems in which individuals have meaningful control over the models, data, and infrastructure providing their inference.
An important distinction is between training models and providing inference. Frontier training may require enormous concentrations of capital, energy, and compute. That doesn't mean the companies that train models must also control how people use them. Even the most capable models should be runnable independently of their creators.
People should be able to keep their data locally and run models on hardware they control whenever feasible, especially where independence matters for safety, as with self-driving cars and home security systems. They should have access to open-weight models they can inspect, modify, and run without anyone's permission.
Where cloud computing is necessary, we need genuine competition among providers that respect user privacy and autonomy. But competition isn't enough. We should develop technical and protocol-based guarantees that limit what even a dominant provider can learn about or do to its users.
Technologies pioneered in cryptocurrency could play a significant role. Zero-knowledge proofs could help verify that computations were performed correctly; homomorphic encryption could enable computing on encrypted user data without revealing it to providers; and blockchain-based protocols could coordinate decentralized computing resources and enable new forms of user ownership. These technologies are at different stages of maturity, but point toward privacy and user control guaranteed by system architecture rather than a company's privacy policy.
Perhaps users could even own part of the infrastructure providing their inference, sharing in its value rather than merely providing valuable data to someone else's business.
There's no reason AI's enormous promise should require surrendering control over our digital lives to a handful of corporations. We can have rapid AI progress and individual technological sovereignty. Indeed, I think the latter is essential if we want the former to be a lasting benefit to humanity.
Liz Highleyman retweeted
This is atrocious
Democrats have a wishlist for AI that includes a federal permit to train a model, a Department of AI, 20-year prison terms for executives, kill switches, and ID checks to use a chatbot. Writing code is about to need a hall pass if certain politicians get their way.
reclaimthenet.org/democrats-…
This isn’t going to be any comfort for the minority of people with persistent severe long COVID, but still positive news that long-term effects have gotten less common in the era of widespread immunity.
cidrap.umn.edu/only-1-4-adul…
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Back on my relative vs absolute risk soapbox. GLP-1s may nearly “double the risk,” which makes for clickable headlines in mainstream media. But the risk remains very low.
“Overall, the incidence rate of NAION was 6.4 events per 100,000 patient years compared to 3.8 events in patients taking a placebo or alternative.”
fiercepharma.com/pharma/fda-…
Not only did Huang have an affair, but he’s subjected her to global public humiliation for looking like a woman of her age who hasn’t chopped up her face & doesn’t wear a ton of garish makeup.
Liz Highleyman retweeted
The Kraken? This is not the language of a serious policymaker. The voters of SC, Iowa, KS, TX, OH are not interested in childish AI slop, convicted rapists as spokespeople for MAHA, or measles. Let’s get serious.





















