Longevity Dad 🏌🏻🏋️💉💪🏼

I'm 58, a husband and a dad, and I'm running my own longevity protocol out loud. Peptides, supplements, lifting, bloodwork. Some of it works, some of it does nothing, and I post both. Not a doctor and not selling you a stack. Just a guy trying to still be doing this in month 9, and month 90.

Creatine is one of the most studied supplements out there, and California is about to card teenagers for it. Starting January 1, stores there can't sell supplements marketed for muscle building or weight loss to anyone under 18. Creatine is one of the ingredients that can put a product in that bucket. Online sellers have to verify age too. I get wanting to keep diet pills and sketchy fat burners away from kids. Lumping creatine in with them seems backwards to me. Should a 16 year old be able to buy creatine? leginfo.legislature.ca.gov/f…

I'm 58 and I don't just want to live longer. I want my 70s to look like my 50s. What's one thing you're doing differently than your parents did at your age?

If you're on a GLP-1 and not lifting, you're probably losing strength along with the fat. That's my takeaway from a new trial in people my age. 120 adults aged 50 to 70, all on tirzepatide for 40 weeks. Both groups lost about 50 pounds. The group that lifted 3 times a week lost 25% less lean tissue and got about 10% stronger. The group that didn't got about 10% weaker. Same drug, same weight loss, very different body at the end. If you're on one, are you lifting? nature.com/articles/s41591-0…

Warren Buffett is 96 and drinks five Cokes a day. I still wouldn't copy a single thing about it. He's one guy who won the genetic lottery. Nobody's interviewing the people who drank five Cokes a day and didn't make it to 70. Who's the person in your family who breaks every rule and still outlives everybody? businessinsider.com/warren-b…

After a week of heart drugs that moved the number but not the events, LDL is the one I'd still bet on. The PCSK9 shots already cut heart attacks. Sinclair's now on Lipfendra, the new daily PCSK9 pill. It cut LDL about 56% vs placebo and ApoB about half. But its own heart attack and stroke trial hasn't reported yet. Would you start it now or wait for that data?

Zone 2 isn't a scam. It's just a lousy plan for a faster half marathon. If the goal is a PR, harder intervals get you there quicker. That's not my goal at 58. I want to still be golfing, lifting, and keeping up with my kids at 75. Easy miles I'll repeat for 20 years beat a perfect plan I quit by March. What's your mix, mostly easy or mostly hard?

Two huge heart trials this week did the exact same thing. The drug crushed the number and the heart attacks didn't budge. One cut Lp(a) 78%. The other, ZEUS, cut CRP 64% and IL-6 76%. Events were 17.6% on the drug vs 17.7% on placebo. I still track my numbers. I just trust the ones tied to fewer events, not a prettier lab report. What's the one number you watch closest? newsroom.heart.org/news/rese…

Everybody in this space talks about Lp(a) like it's destiny. A huge trial just tested dropping it. About 8,300 people with heart disease got a monthly shot (pelacarsen) for almost 5 years. Lp(a) fell 78%. Heart attacks and strokes didn't move (12.3% vs 12.1%). They already had heart disease, and most were on statins with decent blood pressure. Not healthy people optimizing a panel. Lp(a) is still worth knowing. It's inherited. This just didn't show that crushing the number later changes events. newsroom.heart.org/news/lp-a… newsroom.clevelandclinic.org… acc.org/latest-in-cardiology…

An old gym supplement is about to get hyped as an anti-aging pill. Not yet. UChicago found vanadyl sulfate works like a senolytic in mice. Fewer zombie cells, better strength and insulin sensitivity, and male mice lived about 7% longer. Mouse study, ~20 per group, zero human data. Not a reason to go buy a bottle. nature.com/articles/s43587-0… biologicalsciences.uchicago.…

Obesity trials still celebrate the scale. Plenty of people quit because they "lost too much," and the paper never made clear what that loss was made of. On semaglutide, about 40% of the drop can be lean. The bathroom number was never the hard part. Composition is.

The "NAD crashes with age, so buy NMN" pitch just took a hit. New data on 1,068 adults and whole-blood NAD. In healthy people it didn't fall with age. Flat in men, went up a bit in women. What it tracked was heart disease and high blood pressure. Blood isn't muscle or brain. But it undercuts that sales line pretty cleanly. nature.com/articles/s42255-0…

Harvard just said the quiet part out loud on workout timing. Pick a slot you can actually stick with. A theoretically perfect hour you skip three days a week loses every time. Consistency beats chronotype. news.harvard.edu/gazette/sto…

My feed is full of 10-item vitamin D deficiency lists today. Night sweats, mood swings, even procrastination. That's not how you figure it out. Get a 25-OH vitamin D blood test. Cheap, specific, and it ends the guessing.

Don't read this as an anti-T study. New mouse preprint. Male mice castrated as adults lived about 33% longer, more than the ones neutered young. The odd part is they didn't age any better. Grip strength dropped at the same rate. Nobody's shown testosterone is the reason yet. science.org/content/article/…

A brain scan that can spot Alzheimer's risk 12 years early, before memory slips, is the kind of tool that actually matters. Stanford built a score from resting brain activity, Alzheimer's on one end and super agers on the other. In 1,300+ people aged 55 to 70 with normal memory, an Alzheimer's-like pattern predicted decline up to 12 years out. Not diagnostic yet. Big question is whether it moves. medicalxpress.com/news/2026-…

Do you remember when you joined X? I do! #MyXAnniversary

25% body weight lost is the headline. What that 25% is made of is the part I care about. Retatrutide phase 3 in NEJM: 80 weeks, 2,339 people without diabetes. The top dose lost 25% vs 3.9% on placebo, and knee pain and sleep apnea both improved. 11% quit the top dose though. And it's still not approved, so gray market vials aren't what was tested. nejm.org/doi/10.1056/NEJMoa2…

Passionate wisdom 👇🏻👇🏻

New Aging Cell paper. They aged human skin cells in a dish for months and the cells picked up the same gene and methylation changes seen in older people. Metformin slowed a lot of that. Rapamycin barely moved it. Cells in a dish, not people. Rapamycin fans won't love it though. pubmed.ncbi.nlm.nih.gov/4296…