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MIT Picower Institute

@MIT_Picower

Dedicated to understanding the mechanisms underlying learning and memory and related brain functions and disease. Profile art by @toddsiler

 Cambridge, Massachusetts
picower.mit.edu
Joined May 2010
  • Tweets3.3K
  • Following1.6K
  • Followers9.2K
We are heartbroken to have lost our founder, who provided so much inspiration, but we are all honored to carry on the science he loved so much. picower.mit.edu/news/picower… #neuroscience #biology
Picower Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86

Picower Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86

Tonegawa made landmark discoveries about how the immune system generates antibody diversity and how the brain forms memories.

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How did Li-Huei Tsai's lab celebrate passing the 100,000 citation mark on Google Scholar this morning? A box of 100 Grand bars in the break room, of course.
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🪱🪼🪰There's still limited time to register for our daylong symposium "Comparative Neuroscience: Lessons from Biodiversity" Nov. 4. docs.google.com/forms/d/e/1F… @MITBiology @mitbrainandcog @ScienceMIT @MITevents
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Mentees, colleagues, friends shared remembrances of Susumu Tonegawa at an Oct. 16 memorial service. picower.mit.edu/news/mentees… @MITBiology @mitbrainandcog @ScienceMIT
Image from MIT Picower Institute (@MIT_Picower)
Image from MIT Picower Institute (@MIT_Picower)
Image from MIT Picower Institute (@MIT_Picower)
Image from MIT Picower Institute (@MIT_Picower)
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New in @CellStemCell: How the biggest Alzheimer’s risk gene disrupts the process of insulating neurons picower.mit.edu/news/how-big… #neuroscience #alzheimers @mitbrainandcog @ScienceMIT
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Study led by Leyla Akay in the lab of Li-Huei Tsai: cell.com/cell-stem-cell/abst…
Genome-wide CRISPR screen reveals that Wnt signaling regulates lipid accumulation in APOE4 oligod...

Genome-wide CRISPR screen reveals that Wnt signaling regulates lipid accumulation in APOE4 oligod...

Akay et al. use a genome-wide CRISPR screen to identify Wnt signaling as a regulator of lipid accumulation in APOE4 oligodendrocytes. Stimulating Wnt signaling by inhibiting GSK3B reduced lipid...

cell.com
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Join us Nov. 4 for "Comparative Neuroscience: Lessons from Biodiversity," our Fall symposium! What can we learn from the differences and similarities across the diversity of nervous systems that have evolved? picower.mit.edu/events/picow… @MITBiology #neuroscience
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In six talks at our @AgingBrainMIT symposium Sept. 25, researchers from across MIT described projects aimed at advancing the understanding of and interventions against neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS picower.mit.edu/news/symposi…
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💼We're hiring! We're looking for an Executive Director to help drive scientific strategy and research development while leading our administrative and financial teams. picower.mit.edu/about/career… #neuroscience #careers #jobs
Careers

Careers

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Join us a week from today for our afternoon @AgingBrainMIT symposium: Innovation for the Aging Brain. Six great talks + Posters. Registration will close on Monday: picower.mit.edu/events/aging… #neuroscience #aging
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We’ve been so touched to hear from so many people since our founder Susumu Tonegawa died. As a tribute to his legacy, MIT has established The Susumu Tonegawa Memorial Fund. Gifts can be made via giving.mit.edu/susumu-tonega… or by emailing memorial-gifts-office@mit.edu.
In a black and white picture, Susumu Tonegawa sits at a table piled with papers and writes on a pad with a pen. Behind him is a whiteboard full of math.

ALT In a black and white picture, Susumu Tonegawa sits at a table piled with papers and writes on a pad with a pen. Behind him is a whiteboard full of math.

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New study in @iScience_CP: How the brain keeps its options straight at decision time: Ensembles of neurons encode information to maximize clarity throughout the process. picower.mit.edu/news/how-bra… #neuroscience @mitbrainandcog @ScienceMIT
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Study led by Huidi Li in the lab @MillerLabMIT: sciencedirect.com/science/ar…
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A new atlas of the striatum reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction and other disorders. It could guide new drug treatments. youtu.be/eQmEKrBMvmo #neuroscience @scienceMIT @mitbrainandcog
A 'roadmap' of the striatum

A 'roadmap' of the striatum

Picower Institute postdoc Raleigh Linville, lead author of a new st...

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News story: picower.mit.edu/news/atlas-b… Study in @CellCellPress: doi.org/10.1016/j.cell.2026.…
Atlas of the brain’s striatum could guide researchers to new drug treatments

Atlas of the brain’s striatum could guide researchers to new drug treatments

A new study reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction, and other disorders.

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New theory! The brain's ability to generate cognition and consciousness arises from analog computations carried out by electrical waves. Review in JNeurosci led by @MillerLabMIT: picower.mit.edu/news/cogniti… #neuroscience @ScienceMIT @mitbrainandcog
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Study with co-authors Scott Brincat and Jefferson Roy: jneurosci.org/content/46/33/…
Analog Cognition and Consciousness

Analog Cognition and Consciousness

Cognition and consciousness may arise from bidirectional interactions between neuronal spiking and rhythmic electric field activity (brain waves). Goal-directed behavior relies on top-down control to...

jneurosci.org
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Flexible brain circuits can switch between different tasks. Neuroscientists have discovered circuits in the prefrontal cortex that can be repurposed to store different types of information. picower.mit.edu/news/flexibl… #neuroscience
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Study led by Yuma Osako in the lab of Mriganka Sur: nature.com/articles/s41593-0…

Reusable modular architecture enables flexible cognitive operations in the mouse brain and artifi...

Nature Neuroscience - Mice flexibly reuse neurons specialized for stimulus processing and memory maintenance, regardless of the content, providing evidence for reusable modular organization in the...

nature.com
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High-speed microscopy reveals electrical activity across the brain. New technique, demonstrated in zebrafish, could help scientists learn how the entire brain works as a whole. picower.mit.edu/news/high-sp… #neuroscience
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+Study led by labs of Ed Boyden and Matt Wilson: nature.com/articles/s41592-0…
Voltage imaging of neurons distributed across entire brains of larval zebrafish

Voltage imaging of neurons distributed across entire brains of larval zebrafish

Nature Methods - Voltage imaging across much of the zebrafish brain is achieved at 200.8 Hz, by optimizing a remote-scanning light-sheet microscope.

nature.com
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New in @ScienceMagazine: A brain circuit that keeps tabs on what just happened to aid judgement of what’s happening now picower.mit.edu/news/brain-c… #neuroscience @mitbrainandcog @ScienceMIT
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Study led by Ning Leow in @SurLabMIT: science.org/doi/10.1126/scie…
A thalamocortical circuit encoding deviations from sensory history

A thalamocortical circuit encoding deviations from sensory history

Prior expectations guide attention and support perceptual filtering during decision-making. In mice performing a visual discrimination task, choices depended on trial-by-trial differences between...

science.org
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Every year, undergrads from across the country visit labs in @MITBiology and @mitbrainandcog labs (and more) to gain research experience. Learn more about the MSRP-Bio program through the lens of two students' experiences in the lab of @JTroyLittleton. youtube.com/watch?v=tpiaFedw…
Summer research in MSRP-Bio

Summer research in MSRP-Bio

Every year, undergraduates from all over the country visit in MIT L...

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Congratulations to Emery N. Brown on earning an honorary doctorate from @UDC_gal honoring his research on anesthesia and the brain! udc.gal/gl/novas/Marisol-Soe… #neuroscience
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With Mass. Women’s Health Award, team will study how Alzheimer’s risk varies with hormone replacement picower.mit.edu/news/mass-wo… #Alzheimers #WomensHealth @MALifeSciences @AgingBrainMIT
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Congratulations to Emery N. Brown on being named an Institute Professor at MIT. It's MIT's highest faculty honor! picower.mit.edu/news/mit-nam… @mitbrainandcog
MIT names Emery N. Brown an "Institute Professor," its highest faculty honor

MIT names Emery N. Brown an "Institute Professor," its highest faculty honor

Brown, a renowned neuroscientist, anesthesiologist and statistician, has made numerous seminal contributions to basic science and clinical care alike. He joins two other professors in earning the...

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