Shining light on organic chemistry and chemical biology
Princeton, NJ
Joined June 2015
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Now out in Nature Communications: nature.com/articles/s41467-0…
Using µMap, we uncovered the engagement of ERα within PML nuclear bodies following treatment with the hormone therapy, fulvestrant.
Congrats to Chun, Zihan, Ciaran, and our BMS collaborators!
Now in @Nature: A novel approach to largely inaccessible dialkyl ether chemical space through heteroatom homolytic substitution (het-Sh2). Huge congrats to the team, Johannes (@GrosskopfJo), Johnny, Jackie, and @Merck collaborators. Give it a read!
nature.com/articles/s41586-0…
Cheers to Taehyun (Tae) Kim, Min Sun (Esther) Kang, and Zihan (Blair) Dong for delivering an awesome Third Year Seminar!
We will miss you, Yuki! We wish you the best of luck, and it was a pleasure working with you in the lab!
Huge congrats to Will, Inji, and Eli on passing their generals exams! 🎉👏 Major milestone achieved—so proud of our grad students! 🧪✨
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We’re hiring a postdoc in collaboration with J&J! The position will be split between our lab and J&J’s Spring House site. We’re looking for someone with a strong chemistry background ideally with expertise in photochemistry and developing photocatalysts.
jj.wd5.myworkdayjobs.com/JJ/…
Our recent JACS paper unveils a metallaphotoredox platform enabling N-alkylation with alcohols, acids, or halides — even in complex drugs & peptides! Opening the door to new C(sp³)-rich drug designs. Congrats, Johannes, Danielle, and Aimee!
pubs.acs.org/doi/10.1021/jac…
Our latest μMap platform in action on @ChemRxiv! In collaboration with BMS we efficiently deconvolute MoAs from a large phenotypic screen, uncovering BACH2 degraders that act via upstream kinases & harness LONP1. A powerful example of rapid MoA resolution
chemrxiv.org/engage/chemrxiv…
Old tissue, new tricks??
We introduce μMap-FFPE—a high-resolution protein photoproximity labeling platform for archived FFPE tissue. Check out this paper for your spatial proteomics needs and to learn more about CD20 in clinical tissue samples.
📃: doi.org/10.1021/jacs.5c06489
Alcohols + aryl acids = C(sp3)–C(sp2) bonds! In collaboration with @LongLabCal & Merck Boston, we combine NHC-deoxygenation & Ni-catalyzed decarbonylation to link overlooked building blocks. Congrats Eva, Johnny, Edna, Stephanie, Kurtis, Cesar & Ryan!
pubs.acs.org/doi/10.1021/jac…
Check out our newest work in Chem to achieve 3-functionalization of BCPs to access diverse aryl bioisosteres. Congrats Kat!
Give it a read here: cell.com/chem/abstract/S2451…
![Rapid access to 3-substituted bicyclo[1.1.1]pentanes](https://pbs.twimg.com/card_img/2119847904827392000/aY9AM1Y1?format=jpg&name=386x202)
Check out our latest work in JACS, where we sort nitrogen-centered radicals and alkyl radicals across alkenes in a regioselective aminoalkylation reaction. Congrats to Will, Johnny, and our collaborator Jesús from Janssen Spain!
pubs.acs.org/doi/10.1021/jac…
Check out this latest work in JACS from Steve, Roderick, Niels, Brandon, Philip, and Iakovos! 🎄 pubs.acs.org/doi/10.1021/jac…
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Nothing like a little holiday cheer in the lab! Our chemistry department got a surprise visit from therapy dogs today—bringing smiles, tail wags, and a much-needed break from the bench. 🐾✨ #LabLife #HolidayCheer #TherapyDogs #ScienceAndSmiles
Check out our latest work in JACS— Access to a nucleophilic Fe(I) complex allows for activation of 1° electrophiles via an SN2-type mechanism. Subsequent SH2 bond formation enables all-carbon quaternary centers. Congrats Andria, Felix, Wei, and Marissa!
pubs.acs.org/doi/full/10.102…
Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! @HuthSean @JacobGeri1 @JamesO760
μMap-Interface: Temporal Photoproximity Labeling Identifies F11R as a Functional Member of the Transient Phagocytic Surfaceome | JACS @Princeton @PrincetonChem #muMap #Photoproximity #Labelling #F11R #Functional #Transient #Phagocytic #Surafeceome pubs.acs.org/doi/10.1021/jac…
Check out our latest article in Nature Chemical Biology where an intracellular micromap proximity labeling platform is established to investigate stress granule disassembly mechanisms. Congrats to Roderick, Steve and Sean!
nature.com/articles/s41589-0…
