Neural Cell News

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White matter invasion underlies the lethality of diffuse #glioblastoma (GBM), yet its microenvironmental drivers remain poorly defined. 🧠 Researchers suggest oligodendrocyte-glioma crosstalk as a therapeutic target in diffuse #GBM. @oncogenejournal | go.nature.com/48a9HEM

🔔 Check out this #OpenAccess @ImmunityCP review providing an overview of the current applications, the challenges and limitations, and future avenues of human brain cellular #xenografts in neuroimmunology and translational research! 🔗 bit.ly/4zvDjIJ

🧠 Researchers from @bcmhouston show that #glioma tumors utilize multiple mechanisms to manipulate the activity of inhibitory #neurons as a means to drive network hyperactivity, which ultimately facilitates malignant progression. Read more in @NeuroCellPress: bit.ly/3UBhicc

In this @sigtrans_sttt study, investigators provide the first high-resolution, spatially mapped, single-nucleus transcriptomic resource from an East Asian #ParkinsonsDisease cohort which may guide the development of ancestry-informed therapeutic strategies. 🌏 Read more in their #OpenAccess article 👉 go.nature.com/4egcKi6.

🚀 Research from @NotreDame presents not only an advanced model of #glioblastoma for basic and translational research but also demonstrates methods to acquire diverse data from #organoids compatible with the unique constraints of in-space systems! Congratulations to first author Alice Burchett Darantiere (@AeroMechND) and her team! Read the @PNASNews paper: bit.ly/3W6QWze

EPSP–spike (E-S) potentiation enhances neuronal output independently of synaptic strength, yet its cellular basis has remained unclear and is often considered secondary to synaptic plasticity. 🧠 This paper in @PNASNews shows that astrocytes actively drive E-S potentiation through sustained calcium signaling and vesicular release of D-serine. Paper 🔗 | bit.ly/4injiwE

💡Scientists from @hkust established the common FAM193B-CCG repeat as an Alzheimer’s disease (AD) risk genetic factor and highlight the contribution of common #StructuralVariants to AD #heritability. @NatureNeuro | go.nature.com/4sq30Yu

In this @NeuroCellPress article, scientists identify μ-crystallin-expressing #astrocytes as modulators of #Huntington’s disease pathophysiology and suggest that restoring μ-crystallin could be beneficial in early disease stages. #OpenAccess 🔗 bit.ly/4dSr14p

🧠 This study in @CellCellPress found that receptor protein tyrosine phosphatase sigma is the host factor mediating #TetanusNeurotoxin trafficking into the #CNS! Congratulations to first authors Pengsheng Chen and Huan Wang, and their team! #OpenAccess🔗 bit.ly/4zyZu05

Researchers including Zhi Geng, Cheng Yuan, and Zeying Yua integrated multi-omics bioinformatics analyses with in vitro and in vivo functional experiments to investigate the role and mechanism of nucleoporin 35 (NUP35) in #glioblastoma glycolytic reprogramming. 🧠 Learn more: bit.ly/47iAMFh

Gabriel Said, Adelino Sanchez Ramos da Silva, and Guilherme da Silva Rodrigues examine evidence connecting exercise, DNA methylation, and Alzheimer's disease (AD), with emphasis on AD-related loci and on the possible intergenerational implications of parental exercise. 🏃 Learn more: bit.ly/3W7FvXQ #OpenAccess

This @NatureGenet study reports a single-cell atlas of alternative polyadenylation of the aged human brain 🧠 across 2 million cells from 379 human postmortem brains across individuals with and without #AlzheimersDisease. Don't miss it: go.nature.com/3Wh7hRI

🚨 A new study published in Advanced Science (@AdvPortfolio) uses 3D bioprinted-spheroids to assess blood–brain–tumor barrier penetration by anticancer drugs and their effects on #glioblastoma. 📑 Read the #OpenAccess article: bit.ly/4rOm2ap

🧠 Read this #OpenAccess review examining midbrain organoid-based #ParkinsonsDisease modeling through a concept-driven lens: bit.ly/3VjmOAl

Limonin ameliorates hyperuricemia-induced cognitive impairments, attenuates neuropathological alterations, modulates microglial polarization, and rescues neuronal apoptosis by targeting the HIF-1 pathway. Read the study: bit.ly/4AQuV7J Led by researchers at Southern Medical University and affiliated institutions. #CognitiveImpairment #Neuroinflammation

In a mouse model of ischemic stroke, a novel multifunctional nanoplatform (RM@HPAN) targeted ischemic brain regions, reduced infarct volume from 29.4% to 3.8%, improved neurological scores, and suppressed oxidative stress and inflammation. Read the study: bit.ly/4hm2C9l Led by first author Shaofa Li and corresponding authors Lanqing Meng and Tong Li. #StrokeResearch #Nanomedicine #Neuroscience

Results from a new study in @Dev_Cell provide evidence that species-specific regulation of proteasome-mediated proteolysis influences the timing of neural development and suggest that evolutionary tuning of proteasomal activity contributes to differences in embryonic developmental pace. Read more about the findings here📕 : bit.ly/4y8FroY

New study in @CellPressNews: research findings unveil a mechanism linking cancer metabolism with cancer neuroscience and leverage human genetics to nominate gluanidinoacetate synthesis as a target in #gliomas. Read more here: bit.ly/4yibjI1 #CancerResearch #Neuroscience

Findings from a new @NeuroCellPress study define inhibitory input as a suppressive component of the #glioma ecosystem and suggest that strengthening inhibitory tone may offer a therapeutic strategy. Read more here📕: bit.ly/4hzcD2W

🚨 New study in @CellCellPress unveils a mechanism linking #cancer metabolism with cancer neuroscience and nominates guanidinoacetate synthesis as a treatment target in #gliomas! Read the full #OpenAccess article here: bit.ly/4yibjI1 🧠