
McAfee Professor of Engineering @MIT; Founder; AI-Driven Scientific Discovery
Cambridge, MA
Joined December 2014
- Tweets7.5K
- Following2.4K
- Followers28.1K
- Likes24.6K
Pinned Tweet
We're one day away from our ScienceClaw Hackathon - see you all tomorrow afternoon Oct 30, 2026 at the @MIT @medialab for an exciting weekend.
Thank you to our sponsors @nvidia , @claudeai, @formlabs, @nebiusai, @EdisonSci, @Stifel Venture Banking, @Google, @romixbio, @askalphaxiv, the @MITEngineering, and @LilaSciences for supporting the event and providing resources for our teams. A dream team of leaders in agentic AI, AI for science, and scaling discovery!
And thank you to our amazing organizing team Habib Haddad, Calvin Chin, @e14fund, Andrea Porras, @fwang108_, @JaimeBerkovich, @SubhadeepPal, Bruno Howard, Awu Chen, Keira Boone, @leemmarom, and @maxwellbauer, and to our judges @evijit, Desiree Plata, Yilun Du, Riken Shah, Ian Ferguson, and @NikitaFedik for contributing their time and expertise.
We are also grateful to the broader community joining us from Hardmode, Sundai, Harvard University, the University of Michigan, MIT, and @ReactorfieldAI, bringing together expertise and perspectives across institutions and disciplines.
Looking forward to seeing what we build together!
Markus J. Buehler retweeted
„Intelligence then grows by _constructing new spaces to think in_.“
„the AI had to reason across long path-dependent histories, simulate alternative _futures_“
„A lot of positive will come out of this because it expands the human _epistemic horizon_“
1/
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate.
Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in.
The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material.
The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms.
A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts!
A few lessons we learned:
▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument.
▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition.
▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
Markus J. Buehler retweeted
ai and beauty
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate.
Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in.
The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material.
The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms.
A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts!
A few lessons we learned:
▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument.
▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition.
▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
Markus J. Buehler retweeted
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate.
Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in.
The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material.
The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms.
A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts!
A few lessons we learned:
▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument.
▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition.
▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
We just concluded the 2026 @theNAEng EU-US Frontiers of Engineering Symposium in Chicago, which I had the pleasure of co-chairing with Paolo Samorì. We designed the program to explore new interconnections across the boundaries of materials, computation, biology, and physical systems. Matter itself becomes intelligent, computation becomes increasingly physical, and AI transforms how we discover and engineer new systems and unprecedented depth and speed. What an incredible event! A special thank you to NAE President Tsu-Jae Liu, Euro-CASE President Eloy Àlvarez Pelegry, University of Chicago President Paul Alivisatos, our local host Matthew Tirrell, and Stephanie Houser from the NAE for speaking at the event and their support.
We saw inspiring science, people, and new connections between different fields:
1️⃣ In generative AI for physics and matter, we explored machine learning for molecular properties and quantum chemistry, differentiable physics as a programming paradigm, and the integration of experiments, large language models, and theory to discover quantum materials.
2️⃣ In soft robotics and bio-integrated materials, biological principles inspire new robotic materials, how organic electronics can form interfaces directly within living tissues, how neuroprosthetics can enable human–machine symbiosis, and how optical transparency can open new windows into biological systems.
3️⃣ In neuromorphic computing, the physics of magnetic, ionic, and organic materials can be harnessed for computation, memory, and learning. These approaches exploit the intrinsic behavior of physical systems to compute.
4️⃣ In water security, we explored engineering across scales - how molecular level nanofluidics and porous materials can enable energy harvesting, new separation technologies, circular chemical manufacturing, and integrated approaches to water and energy infrastructure across sectors.
Frontiers of Engineering is a prestigious, highly selective program run by the NAE to bring together outstanding early-career engineering leaders from academia, industry, and research institutions. A huge thank you also to our excellent session leads Perla Maiolino, Sihong Wang, Gábor Csányi, Venkat Viswanathan, Sayeef Salahuddin, Yoeri van de Burgt, Amy Pruden, and Volker Presser, and to the NAE, Euro-CASE, the University of Chicago, and the organizing team.
And especially, thank you to all our brilliant speakers for sharing their science, ideas, and perspectives.
Congratulations to everyone on becoming NAE Frontiers of Engineering Alumni!
Markus J. Buehler retweeted
Nice to win a hackathon @MITEngineering this weekend. 2nd overall. 1st @askalphaxiv. 1st @nebiusai.
Very happy that Google AI co-scientist co-inventor @kk_VirtualVerve approached me at the last @foresightinst event and told me about how she thinks symbolic logic needs to be included in the next generation of AI tooling then convinced me to come by @ProfBuehlerMIT 's most excellent Science Claw event at @medialab along with an epic team that included Kris Ganjam from the @AllenInstitute, @ashleycaselli from Nanopublications, and @xX_itsamit_Xx from the Broad Institute.
Very happy for the support of @e14fund @claudeai @GeminiApp
Also thanks to @drmichaellevin @samsenchal @allisondman @trentmc0 @alex_pentland for inspiring parts of the design.
We’re hiring an Executive Director for the MIT AI Exchange - this is a great opportunity to help shape how MIT advances AI in research and learning, working with faculty and colleagues across the Institute to build programs, capabilities, and partnerships. Please share with anyone who might be interested and consider applying. Link in reply.
More information and application details: ois.mit.edu/executive-direct…
3
410
Markus J. Buehler retweeted
Over the weekend, 150+ hackers built agent systems to solve science problems at MIT’s ScienceClaw Hackathon @ProfBuehlerMIT @fwang108_
alphaXiv sponsored prizes for teams who reached the most scientifically meaningful results with OpenResearch
Here are some things people built:
Models improving and editing models directly in weight space - wild! Exciting work from my colleagues at MIT…opening interesting new possibilities
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math.
It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training.
We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵
Blog: rikiyat.github.io/blog/weigh…
Readers added context they thought people might want to know
LLM was given weights explicitly as text in prompt and used code/forward passes (per authors' logs) to ablate Qwen looping direction, a known thinking-mode issue per model card. Primarily fixed repetition in that mode, not general 'natively' improving weights/math.
rikiyat.github.io/blog/weight-sp…
github.com/RikiyaT/lm_und…
huggingface.co/Qwen/Qwen3.5-0…
huggingface.co/RikiyaT/Qwen3.…
Markus J. Buehler retweeted
proud to support ScienceClaw with @ReactorfieldAI scientists + builders hacking on AI for science all weekend at the @medialab. doing startup office hours today, come say hi!
And...we're launched! We kicked off the ScienceClaw Hackathon with @e14fund yesterday - incredible energy in the room with people from all around the US and beyond pushing the interface of AI and science!
Thank you to our sponsors @nvidia @claudeai @openai @formlabs @nebiusai @EdisonSci @Stifel Venture Banking, @Google @romixbio @askalphaxiv @MITEngineering @LilaSciences @ReactorfieldAI Sundai and more
And...we're launched! We kicked off the ScienceClaw Hackathon with @e14fund yesterday - incredible energy in the room with people from all around the US and beyond pushing the interface of AI and science!
Thank you to our sponsors @nvidia @claudeai @openai @formlabs @nebiusai @EdisonSci @Stifel Venture Banking, @Google @romixbio @askalphaxiv @MITEngineering @LilaSciences @ReactorfieldAI Sundai and more
We're one day away from our ScienceClaw Hackathon - see you all tomorrow afternoon Oct 30, 2026 at the @MIT @medialab for an exciting weekend.
Thank you to our sponsors @nvidia , @claudeai, @formlabs, @nebiusai, @EdisonSci, @Stifel Venture Banking, @Google, @romixbio, @askalphaxiv, the @MITEngineering, and @LilaSciences for supporting the event and providing resources for our teams. A dream team of leaders in agentic AI, AI for science, and scaling discovery!
And thank you to our amazing organizing team Habib Haddad, Calvin Chin, @e14fund, Andrea Porras, @fwang108_, @JaimeBerkovich, @SubhadeepPal, Bruno Howard, Awu Chen, Keira Boone, @leemmarom, and @maxwellbauer, and to our judges @evijit, Desiree Plata, Yilun Du, Riken Shah, Ian Ferguson, and @NikitaFedik for contributing their time and expertise.
We are also grateful to the broader community joining us from Hardmode, Sundai, Harvard University, the University of Michigan, MIT, and @ReactorfieldAI, bringing together expertise and perspectives across institutions and disciplines.
Looking forward to seeing what we build together!
Wonderful welcome to Cambridge, Massachusetts @ycombinator @agupta - let’s partner on some events if you’re up for it!
Cambridge has always been the best place in the world to be an academic researcher. These days, a lot of cutting edge research also happens in industry, and Cambridge is the home to many amazing research startups, spanning AI research, robotics, biotech, defense, and industrials.
We'd love for these two worlds to meet eachother, so we're bringing YC Paper Club to Cambridge!
if you're a researcher in industry or academia, request a spot below.
1
11
1,062
Markus J. Buehler retweeted
The language of physics has evolved from early numerals to mathematical equations, computational models, and now the AI era, where representations are learned, integrated, and shared. Each transition has expanded what we can describe, calculate, predict, and discover. Now scientific representations themselves become adaptive, interconnected, and compositional, evolving through data, reasoning, and interactions among models and agents. This opens new pathways for scientific discovery.
Bytes for the win
I've always believed that intelligence should come from simple, general building blocks that learn their own abstractions directly from raw data; in other words, the bitter lesson. I think we're finally seeing a real step towards AI that can learn from all data.
Language modeling on raw bytes is a microcosm of this ideal, and to me it's a central problem in AI: if we can't build LLMs that learn end-to-end from bytes, how will we handle the rest of the world's data that we understand even less?
Last year we introduced hierarchical networks (H-Nets) as a first step. Our new version finds up to 3-5x efficiency gains in controlled scaling law experiments, and at larger scale matches an open-source model trained on 11T tokens with ~10x less data and compute. The posts below walk through what we found and why we think it works.
Fascinating progress at the nexus of reasoning and physics
AI’s advances in sophisticated reasoning are opening new possibilities for discovery in the physical world to design, model and build new forms of matter, atom by atom. With AI reaching for solutions of Millennium problems, the next frontier is connecting that reasoning to physical mechanisms, experiments and manufacturing. We will cover these exciting developments in my hands-on MIT Professional Education short course, Generative Multiscale Materials Design: Physics, AI, Manufacturing, to be held June 28-July 1, 2027, on campus or live online.
Through hands-on clinics and projects, we will explore how to build these workflows using cross-disciplinary multi-scale modeling and agentic AI with decentralized swarms. Topics include connecting knowledge across disciplines, generating and testing material designs, and linking scientific reasoning with autonomous experimentation and additive manufacturing, with applications spanning aerospace composites, self-healing biomaterials and protein design.
June 28-July 1, 2027 - MIT campus or live online
Application link in response
Application link: professional.mit.edu/course-…
4
399


















