Sam Davis (@SamDavisBio) header
Sam Davis (@SamDavisBio) profile picture

Building CoFormBio https://xitter.twitterapi.xyz/t.co/WL2biDcrtV | Ex-EQRx (a16z, Arch, GV) - sold to $RVMD, Ex-Scipher (Khosla), Ex-Goodwin | China expert | ☘️ Celtics | 我叫王明 杰 | سام

Los Angeles (via Boston)
Joined October 2010
Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)Photo by Sam Davis (@SamDavisBio)
The approval committee of Anthropic's Life Sciences Verification Program (LSVP) bookmarking tweets of every biotech operator dunking on Dario’s “cures in 10 years” statement.
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The Biotocracy is up in arms about the “cure all diseases in 10 years” comment. Future cure ≠ FDA Approval (2026) Will the regulatory pathways and timelines look different in 2031, 2036? YES Could there be a scientific breakthrough tomorrow, that the scientific consensus could not conceive of yesterday? YES Just look at the recent DREADDs data for epilepsy that stunned. e/acc
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"Now it also turns out the quality of the work [in China] is outstanding because guess who's doing it? A lot of Chinese scientists who got their PhDs in the United States and then we kicked out because we're….”
.@dawallach explains why China's rise in drug development could be a bigger disruption to the biopharma industry than AI: "Over the past 5-10 years, China has both invested tremendously in early stage development, like discovery work, and pre-clinical biotech outsourced labor." "In China, what they have tried to do is [all the work we do in America] at a quarter of the price. And because the big pharma companies are multinationals, increasingly they've been comfortable doing that work in China." "Now it also turns out the quality of the work is outstanding because guess who's doing it? A lot of Chinese scientists who got their PhDs in the United States and then we kicked out because we're idiots." "China is ascendant and now the lifeblood of big pharma, which is buying new drugs from little biotech companies. Now they are buying double-digit percentages of their new drugs from China."
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I will be in Boston next week (11/10-11/14) for the Decoding Bio Investor Summit; and also for investor and partner meetings for my AI x Bio immunology startup, CoFormBio. Drop a DM if you’d like to meet.
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I don't understand. They used a bunch of open/closed-source tools to screen a tiny virtual library and are complaining they didn't generate a working drug? Those are two entirely different design objectives. What does working even mean in this context? I can't believe this is the state of discourse. Using computers to make medicines has been and will continue to be central to the art. Small molecule tools are lagging behind biologics. They'll catch up. I think everyone knows this. Non-story.
‘“That’s complete BS,” said Jeff Leiden, executive chairman of Vertex Pharmaceuticals. Vertex has used roughly 50 AI companies to comb through its data set of 10,000 drug compounds, Leiden said. Not one managed to generate a working drug.’ 👇🏼 wsj.com/tech/ai/silicon-vall…
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This is well done; I encourage everyone to read the comment, and understand what is really at stake.
Having waded through 163 pages of the draft COINS rule published by Treasury, my team and I can now respond with a simple graphic. It will blind US companies and undermine our biopharma capabilities and national security, exactly opposite to what the policy is aiming to achieve. It does nothing to actually block a Chinese biotech from commercializing a drug in the US, with a European partner, European investors, or on its own. We value medicines highly and will now be paying others for them. Why would we do this to ourselves? We shouldn’t. But you can’t submit a comic to Treasury so we wrote out a detailed comment that both lays out how the draft rule would backfire on American biotech and what revisions would allow Treasury to better achieve their stated national security objectives. Have a look. Biotech investors and executives are welcome to sign onto our comment but the main purpose of publishing it now is to drive discussion that helps everyone sharpen their thinking and informs their own comment to Treasury, due Dec 7th. Anyone is welcome to crib from this. No need to ask. We wrote it after considerable input from legal experts and peers. Since coins draft rule is itself unclear on many points, reasonable people can disagree as to its intent and meaning, so some of our comments address broader points meant to encompass a range of possibilities. If you read what Treasury wrote, you might get the sense that they know this will backfire on America and are looking for support to revise their language to avert harm. So give this thought and submit your own analysis. We provide links in the article to the submission page. And thanks to all who have already signed on. @NPLB_org racap.com/rapport/comment-fr…
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While the world focuses on election results, 33M people across the US, EU5, Canada & Japan live with moderate-to-severe immune-mediated disease, and >90% (31M) still don’t achieve full remission or access advanced therapy. CoFormBio is building therapies for the >90% left behind.
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Sam Davis retweeted
I’ll take that bet.
Agree 100% but unlikely it will come from the big bio companies
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Anthropic within 24hrs of an incumbent calling BS: BS you say? anthropic.com/research/early… @AnthropicAI cc @Prof_Oak_
As someone who has helped companies pioneering the use of AI for drug discovery, this is BS. Sure, AI is a tool that we all should deploy to the best of our abilities, but the idea that AI is going to unveil new medicines at a stunning rate the way it will upend cinema, video games, financial services, advertising, gambling, etc., is a bit absurd. New medicine discovery will be one of the laggards in terms of AI revolution. Healthcare provision, diagnostics, and paperwork streamlining will all move ahead faster. Biology will continue to eat everything, AI included.
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It about execution.
there is no moat
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For all the bispecific bulls, another one bites the dust. Key comment: "Lutikizumab’s safety and tolerability profile could also support combinations, for example, with AbbVie’s anti-TL1A antibody, ABBV-701. Combinations could improve responses, the analysts said." fiercebiotech.com/biotech/ab…
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