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Science Advances

@ScienceAdvances

Science Advances is an open-access multidisciplinary journal, publishing impactful research papers and reviews in any area of science.

 AAAS - Washington, DC
science.org/journal/sciadv
Joined February 2014
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New research suggests that identifying pathway-specific modes of recruiting actin regulators can help define how signal precision is maintained in dynamic tissue environments. Learn more this week in Science Advances: scim.ag/4BLBfh4
Section of a mouse neural tube stained with phalloidin to visualize filamentous actin protein. The formation of pathway-specific cytonemes, actin-based “highways” that guide delivery of morphogen and growth factor signals to distant target cells, remains largely undefined. Daly et al. analyzed the development of Sonic Hedgehog cytonemes and signaling sequences in mouse embryos, finding that repurposing cell adhesion molecule-related proteins BOC and CDON to recruit actin regulators promotes cytoneme elongation and precise information flow. Their study suggests that identifying pathway-specific modes of recruiting actin regulators can help define how signal precision is maintained in dynamic tissue environments. Credit: Christina Daly

ALT Section of a mouse neural tube stained with phalloidin to visualize filamentous actin protein. The formation of pathway-specific cytonemes, actin-based “highways” that guide delivery of morphogen and growth factor signals to distant target cells, remains largely undefined. Daly et al. analyzed the development of Sonic Hedgehog cytonemes and signaling sequences in mouse embryos, finding that repurposing cell adhesion molecule-related proteins BOC and CDON to recruit actin regulators promotes cytoneme elongation and precise information flow. Their study suggests that identifying pathway-specific modes of recruiting actin regulators can help define how signal precision is maintained in dynamic tissue environments. Credit: Christina Daly

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A new study finds a group of neurons within the lateral parabrachial nucleus of the brainstem respond to cold temperatures by releasing enkephalin, a neuropeptide that reduces pain signals. The results mark a potential therapeutic strategy for pain relief. scim.ag/4ixqkii
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A new toothbrush generates electricity through bristle movement to battle plaque-producing bacteria. scim.ag/3Wt6g9q
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Age reshapes how melanoma evolves, according to a new study showing that patient age alters natural selection on cancer-driving mutations. The same mutation can have different effects on the genetic evolution of melanoma depending on the patient’s age. scim.ag/3X5pLoF
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A new study on hibernation shows early cellular changes in Alzheimer’s disease may be a natural adaptive process. Hibernation-induced inflammation is similar to the response in Alzheimer’s disease without amyloid beta accumulation or neurodegeneration. scim.ag/4sFHNtz
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A new study finds that stabilizing the interferon protein IFNAR1 restores T cell function, enhancing the efficacy of immunotherapies for colorectal cancer. scim.ag/4ioCEmj
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A new method can determine where people’s brains lie on the SuperAger to Alzheimer’s continuum. scim.ag/4BPm5ro
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The use of mercury by the ancient Maya for ceremonies, religious events, and decoration spread the pollutant even further throughout the Yucatán region than previously known. scim.ag/4zrLQw5
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Good conversation between two people involves “pink noise,” according to new research. This term refers to fluctuations in semantic similarities—alignments in speech patterns and word choice—across time scales during a chat. scim.ag/4eg9Cme
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Newly documented traces of hydrogen chloride—a stinky gas often produced by magmatism—in the Martian atmosphere corroborates emerging evidence that suggests the planet is still volcanically active. scim.ag/48EnCmp
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A new study describes the Multimodal Ultrasound System for Injury Care device, which helps visualize spinal cord structure and track blood flow speed and velocity after surgery. Learn more in this week’s issue of Science Advances: scim.ag/4sJDyxh
Artistic concept of the Multimodal Ultrasound System for Injury Care, or MUSIC device, which uses ultrasound to reveal the spinal cord’s inner structure after decompression surgery. Currently, direct observation of spinal cord physiology following spinal decompression surgery for acute spinal cord injury is challenging. Kerensky et al. designed the implantable MUSIC device to aid visualization of spinal cord structure and track blood flow speed and velocity after surgery. Their findings may enable postoperative spinal cord monitoring and management through sound-based ultrasound technology. Credit: Laura Roy, CMI / LauraRoyStudios.com

ALT Artistic concept of the Multimodal Ultrasound System for Injury Care, or MUSIC device, which uses ultrasound to reveal the spinal cord’s inner structure after decompression surgery. Currently, direct observation of spinal cord physiology following spinal decompression surgery for acute spinal cord injury is challenging. Kerensky et al. designed the implantable MUSIC device to aid visualization of spinal cord structure and track blood flow speed and velocity after surgery. Their findings may enable postoperative spinal cord monitoring and management through sound-based ultrasound technology. Credit: Laura Roy, CMI / LauraRoyStudios.com

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A new study shows that climate-driven shifts in plant community structure, rather than peat decomposition alone, may threaten the stability of peatland ecosystem functions in the future. scim.ag/4ix3p6V @yiqiluo
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A new study offers insights into cancer prevention and therapy through the construction of a pan-cancer microbial epitope landscape from 1190 samples across 24 types of cancer. scim.ag/4znisqS
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Scientists have developed a self-powered, finger-worn interface that converts fingertip movement directly into wireless communication signals. scim.ag/4yVr2My
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Researchers have deorphanized the G protein–coupled receptor GPR88, identifying C1ql1 as its ligand, which bridges it to the postsynaptic receptor BAI3. scim.ag/3WfcTMz @ShenzhenBayLab @PKU1898
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During the devastating 2025 Los Angeles Eaton firestorm’s peak, airborne lead concentrations exceeded 80 times the normal background levels. The research establishes that this urban smoke plume was far more hazardous than a wildland plume the year prior. scim.ag/3Wki5i8
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A new Review discusses how concepts and methods borrowed from psychology can inform research to evaluate whether and how large language models can employ reasoning. scim.ag/3UXqKXp
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Dams may not be producing as much greenhouse gas emissions as thought, new research argues. scim.ag/4zisjOt
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Scientists report photosynthesis-empowered chimeric cells that serve as a generalizable, energy restoration therapeutic strategy, providing effective treatment for various types of degenerative diseases. scim.ag/3UsbDVO
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If you think one spider is scary, how about more than 1000? 🕷️ On #Halloween, learn more about this 2022 research that revealed essential amino acid motifs in spider silk by analyzing genotypes of 1098 spider species. scim.ag/4iaaOKn
1000 spider silkomes: Linking sequences to silk physical properties

ALT 1000 spider silkomes: Linking sequences to silk physical properties

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