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The Science of Parkinson's

@ScienceofPD

Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂

 London, England
scienceofparkinsons.com
Joined January 2016
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Results of the SHARE-PD study have been published. It evaluated MONIPAD (a smart device) use for monitoring #Parkinsons symptoms in 110 people; "Remote monitoring...significantly improved clinical outcomes, QoL, & patient satisfaction in patients with PD" prd-journal.com/article/S135…
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New review explores cell death: from basic principles to translational developments - #Parkinsons gets a few mentions nature.com/articles/s41392-0…
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Image from The Science of Parkinson's (@ScienceofPD)
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With sensitivity of >80% (similar to neuropath), a prospective study evaluating submandibular gland biopsies with Real-Time Quaking-induced conversion suggests that the assay "may serve as a valuable instrument to improve the diagnosis of #Parkinsons" neurology.org/doi/10.1212/WN…
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Image from The Science of Parkinson's (@ScienceofPD)
Image from The Science of Parkinson's (@ScienceofPD)
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An editorial associated with this research: neurology.org/doi/10.1212/WN…

Sensitive Detection of Misfolded α-Synuclein in Submandibular Gland Biopsy Using RT-QuIC Testing in...

neurology.org
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Data from the The Austrian #Parkinsons Disease Registry (Österreichisches Parkinson Register, ÖPAR) reports 72.7% of PD patients "were generally interested in clinical trial participation" prd-journal.com/article/S135…

Interest in clinical trial participation in Parkinson's disease: Insights from a nationwide registry

To compare (socio-)demographic, clinical, and functional characteristics of Parkinson's disease (PD) patients interested in clinical trial participation with those who are not.

prd-journal.com
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Researchers present KBN2201, a hybrid ester of 2-hydroxy-4-trifluoromethyl benzoic acid & pyruvate which restored mitochondrial protein-import components while preserving dopamine neurons & improved motor function in a chronic MPTP model of #Parkinsons sciencedirect.com/science/ar…
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Data from a prospective longitudinal study of 501 participants in the Stanford #Alzheimers Research Center was used to assess "plasma P-Tau217 as a prognostic, monitoring, & risk-stratification biomarker of clinical progression in Lewy Body Disease" neurology.org/doi/10.1212/WN…
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Image from The Science of Parkinson's (@ScienceofPD)
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In Lewy Body Disease, higher baseline plasma pTau217 was associated with faster Clinical Dementia Rating-Sum of Boxes [CDR-SB] increase (β = 0.30; 95% CI [0.14, 0.45]; p < 0.001), MoCA decline (β = −0.35; 95% CI [−0.57, −0.13]; p = 0.002), & cog. index decline (all p ≤ 0.028)
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Nice to see the preclinical data of Teitur Trophics's agent TT-P34 in different models of neurodegeneration (including #Parkinsons) being published. TT-P34 is a SorCS2-derived macrocycle entering clinical testing link.springer.com/article/10…
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Image from The Science of Parkinson's (@ScienceofPD)
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Interesting: The APOE Christchurch mutation reduces #Parkinsons-associated α-synuclein pathology in a mouse model of Lewy body disease; APOE CC binds α-syn more strongly than APOE WT cell.com/cell-reports/fullte…
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Useful news piece on the new era for cell therapies in #Parkinsons nature.com/articles/s41587-0…
A new era for Parkinson’s: this time with better stem cells

A new era for Parkinson’s: this time with better stem cells

Nature Biotechnology - Stem cell therapies for Parkinson’s disease are showing promise in early-stage trials, but companies will need to further optimize the dopamine-producing cell implants...

nature.com
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New research from @BernasconiFosco @OlafBlankeLab et al finds that, while slow waves during sleep have physiological benefits, exacerbated daytime sleep-like slow waves are associated with hallucinations & poorer cognition in #Parkinsons science.org/doi/10.1126/scit…
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New clinical trial registered: A new exploratory study of UX-DA003 - an allogeneic stem cell therapy developed by UniXell Biotechnology - has been initiated in 12 people with #Parkinsons clinicaltrials.gov/study/NCT…
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New clinical trial registered: An open-label, non-randomized, Phase 1/2a single ascending dose study has been initiated by Kanglin Biotechnology to evaluate the safety, tolerability, & efficacy of an AAV9 gene therapy KL002 in 12 people with #Parkinsons clinicaltrials.gov/study/NCT…
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No mention on the internet as to what KL002 actually does... I hope the participants are being told... Perhaps @NCBI should make disclosure of MoA an prerequisite for registration on the CT gov website
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New clinical trial registered: The Stanford University Neurofiber Study (SUNs) will test how a daily fiber bar affects bowel function & gut inflammation in 50 people with #Parkinsons & in household members who live with them clinicaltrials.gov/study/NCT…
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The liver disease drug Ursodeoxycholic acid (UDCA) is joining the world's largest trial of disease modifying treatments for #Parkinsons as its third active treatment arm of the @EJS_ACT_PD platform sheffield.ac.uk/news/drug-di…
Drug discovery by Sheffield scientists joins world's largest trial of Parkinson's treatments

Drug discovery by Sheffield scientists joins world's largest trial of Parkinson's treatments

Sheffield researchers discovered that an existing liver drug could potentially slow the progression of Parkinson’s disease

sheffield.ac.uk
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If you are an early career researchers looking for experience on a grant evaluation committee have a look at this. Cure Parkinson's @CureParkinsonsT offers 2-3 seat on our committee to ERCs every year (4 meetings) Just one week to go before the deadline! cureparkinsons.org.uk/2026/0…
Applications for our 2027 research committee internship programme are now open - Cure Parkinson's

Applications for our 2027 research committee internship programme are now open - Cure Parkinson's

We are inviting applications for early-career researchers (ECRs) to join our research grant evaluation committee as part of our annual internship scheme.

cureparkinsons.org.uk
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We are looking for early career #Parkinsons researchers (PhD students or Postdocs working in the UK) to get 12 months experience on the @CureParkinsonsT Grant Evaluation committee. There are 4 meetings per year & you will be provided with mentoring
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It involves: Meeting #1: You observe (virtual meeting) Meeting #2: You contribute to the discussion (hybrid) Meeting #3: You are a secondary presenter of a grant application (virtual) Meeting #4: You are primary presenter for a grant application (in person meeting+nice dinner!)
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