Cancer Systems Biology
Weizmann Institute of Science
Joined July 2019
- Tweets156
- Following136
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Tirosh Lab retweeted
IDH-mutant gliomas often progress slowly, but inevitably recur and progress. Are there spatial organizing principles at the level of cell states that repeat across tumours during stages of tumour progression?
cell.com/cancer-cell/fulltex…
Out this week in @Cancer_Cell, our work with @RouvenHoefflin, @TiroshLab, @MarioSuva, @GaliliNoam, and Christopher Mount quantitatively maps two independent axes of tumour organization, revealing how they emerge at different stages of progression and in distinct tissue contexts. We hope that understanding these recurring spatial patterns and associations will reveal new opportunities to halt tumour progression.
Tirosh Lab retweeted
🧵1/ Happy to share our new study:
"Spatial analysis reveals the evolving organization of IDH-mutant glioma"
We asked: How is spatial organization established in glioma before the hypoxic architecture of advanced disease emerges?
cell.com/cancer-cell/fulltex…
ALT Graphical Abstract
Tirosh Lab retweeted
👉The Curated Cancer Atlas.
Impressive: “124 scRNA seq datasets for >40 cancer types, with improved data annotations, visualizations and exploration”.
From Michael Tyler and @TiroshLab
@WeizmannScience
nature.com/articles/s43018-0…
Tirosh Lab retweeted
Important publicly available resource from @TiroshLab @WeizmannScience in @NatureCancer
The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution
nature.com/articles/s43018-0…
124 single cell datasets across 40 cancers, >2800 samples.
Tirosh Lab retweeted
1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @M_Nomura, Kevin C. Johnson and Luciano Garofano, which was published @NatureGenet!
nature.com/articles/s41588-0…
Tirosh Lab retweeted
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! nature.com/articles/s41588-0… , nature.com/articles/s41588-0…
Tirosh Lab retweeted
Now online in @CD_AACR: #Glioblastoma-Cortical #Organoids Recapitulate Cell State Heterogeneity and Intercellular Transfer - by Vamsi Mangena, @RChanoch, Paola Arlotta, @tiroshlab, @MarioSuva, & colleagues doi.org/10.1158/2159-8290.CD… @broadinstitute @weizmannscience @MGHCancerCenter
Tirosh Lab retweeted
Very excited to share our work published in @GenomeMedicine on the mesenchymal state of glioblastoma! @TiroshLab @MarioSuva
New #braincancer research from @RChanoch @MarioSuva & co @WeizmannScience which combines multiple #Glioblastoma datasets to define a core mesenchymal program & highlight 3 main MES states with distinct functional, genetic & environmental associations
bit.ly/3dyMfrT
Tirosh Lab retweeted
Very nice resource by the @TiroshLab that provides access to >70 cancer scRNAseq datasets - collected in one place, annotated and analyzed. weizmann.ac.il/sites/3CA/ #EESMetastasis @embl @EMBO
Tirosh Lab retweeted
Our paper is out!!! Thank you Nofar and Tamir for leading this work, and our collaborator Prof. Guy Ron, whom we converted from nuclear physics to cancer research!
Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas cell.com/molecular-cell/full…
Tirosh Lab retweeted
new out in Nature: nature.com/articles/s41586-0…
Tirosh Lab retweeted
Invitation to field to discuss: what are some of the big, open, *conceptual, biological* questions in the single cell field? No tech, no atlases, please :). @NimwegenLab
Tirosh Lab retweeted
העבודה הראשונה שלי מהדוקטורט עלתה השבוע כפרה-פרינט לכבוד הכנס #SNO2021 שבו הצגתי אותה. הציוץ הזה אמנם מסביר אותה היטב אבל שווה להסביר גם קצת בעברית לטובת הקהל הרחב, אז נתחיל.>
Excited to share our preprint by @AvishaySpitzer, @GritschSimon, @MarioSuva, Dan Cahill and @KeithLigon5, demonstrating that mutant-IDH inhibitors (mIDHi) act as differentiation therapy in Oligodendroglioma (OG).
medrxiv.org/content/10.1101/…
Tirosh Lab retweeted
Thrilled to share our preprint by @AvishaySpitzer, @GritschSimon, a close collaboration with @TiroshLab, Daniel Cahill and @KeithLigon5, demonstrating that mutant-IDH inhibitors (mIDHi) act as differentiation therapy in Oligodendroglioma (OG). medrxiv.org/cgi/content/shor…
Tirosh Lab retweeted
A new and phenomenal resource, comprehensive genomic&proteomic data on ~100 GBMs by the CPTA Consortium cell.com/cancer-cell/fulltex…
Tirosh Lab retweeted
The Glioma Stem Cell Model in the Era of Single-Cell Genomics.
Our 2 cents on glioma stem cells with @TiroshLab now online.
@MGHPathology @MGHCancerCenter @broadinstitute @sontagfdn cell.com/cancer-cell/fulltex…
Tirosh Lab retweeted
Bravo to Our department member Yardena Samuels and her team/collaborators for this great work 👏👏👏 cell.com/cell/fulltext/S0092…
Tirosh Lab retweeted
Check out our @PNASNews paper on 10K gene #spatialtranscriptomics by #MERFISH with ∼80% detection efficiency: pnas.org/content/early/2019/…
We infer #RNAvelocity in situ + pseudotime to reveal genes with #cellcycle dependent expression + more
#singlecell #bioinformatics #BigData
Tirosh Lab retweeted
Dead cells do tell tales, or at least they keep making cytokines to tell the immune system to clean up the mess #necroptosis #zombies bit.ly/2Uomo7T
