The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Cambridge, MA
Joined November 2014
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Our November issue is now live!
On the cover—the escape route for Gemella morbillorumand its path to driving colorectal tumorigenesis
cell.com/cell-host-microbe/c…
Timing the feast: Circadian control of rhizosphere nitrogen supply
Preview of work revealing rice circadian regulator Nhd1 uses rhythmic signals to synchronize microbial nitrogen cycling w/plant uptake & assimilation, providing example of “chronoculture"
cell.com/cell-host-microbe/a…
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Featured Article: Rice circadian clock coordinates rhizosphere to optimize N acquisition
Clock component Nhd1 drives rhythmic root exudation to regulate microbial Nitrogen turnover.SynC microbes matching rice Nhd1 rhythm boost grain yield & N use efficacy
cell.com/cell-host-microbe/f…
A gut mucin muncher signals protection in the uterus
Highlight of work linking gut bacterium Akkermansia muciniphila to tyrosol production. In a mouse model, tyrosol reaches the uterus and protects against endometritis, inflammation of the uterine lining.
cell.com/cell-host-microbe/a…
Featured Article: Akkermansia protects against endometritis
A. muciniphila protects against endometritis by driving tyrosol production, which reaches uterus & suppresses inflammation. Work reveals gut-uterus axis linking microbiota to reproductive health
cell.com/cell-host-microbe/a…
Molecular mimicry arrests the phage packaging AppA-ratus
Preview of work finding Salmonella Gifsy-1 prophage protein, AppA, disrupts virion assembly by mimicking terminase assembly interface & arresting phage DNA packaging, supporting bacterial infection
cell.com/cell-host-microbe/a…
Featured Article: Salmonella-phage networks
Profiling >1,000 global Salmonella-phage interactions reveals layered resistance & contribution of surface architecture to defense. AppA blocks phage DNA packaging via mimicry of terminase assembly interface
cell.com/cell-host-microbe/f…
A microbial sugar tips the metabolic scales
Preview of work identifying a Clostridium immunis-derived exopolysaccharide that reduces IL-22 signaling to reshape visceral adipose immunometabolism, linking microbial chemistry to host energy balance
cell.com/cell-host-microbe/a…
Featured Article: Commensal sugar protects against obesity
Clostridium immunis & its bioactive phosphocholine-modified exopolysaccharide (EPS) reduces visceral adiposity & weight gain. By decreasing IL-22, EPS increases metabolic activity in visceral fat
cell.com/cell-host-microbe/f…
Microbial-derived methotrexate metabolite alleviates inflammation
Gut microbial metabolism of methotrexate generates DAMPA. DAMPA acts through STAT3 to promote mitochondrial function and protect against inflammation in context of IBD.
cell.com/cell-host-microbe/f…
Weekend revisit: Probiotics eradicate glioblastoma
E. coli Nissle produces bispecific engagers to recruit & instruct in situ-edited CAR macrophages. Microbe-guided CAR macrophages overcome glioblastoma antigenic heterogeneity & establish antitumor memory
cell.com/cell-host-microbe/a…
Hot paper revisit 🔥
lncRNA induces trained immunity against TB
Exosomal lncRNA TRCR1 derived from Mtb resisters induces trained immunity via CLOCK-mediated epigenetic reprogramming. Mycobacteria induces TRCR1+ exosomes, boosting immunity & BCG efficacy
cell.com/cell-host-microbe/a…
Microbial products trigger chemosensory dialogues via GPCRs
Libraries of gut metabolites+GPCR-seq reveal how gut senses environmental chemicals. ID microbial products activating specific receptors, including those triggering serotonin or linking to IBD
cell.com/cell-host-microbe/a…
Distinct BSHs in Bacteroides limit VRE
Bacteroidales mediate resistance to Vancomycin-resistant enterococci via subtype of bile salt hydrolases that retain uncleaved N-terminal signal peptide. T5 BSHs generate DCA that limits VRE
cell.com/cell-host-microbe/a…
Cell Host & Microbe retweeted
✨#SUSTech researchers publish new findings in @cellhostmicrobe, dissecting the complete immune pathway of the bacterial DRT2 antiphage defence system. This work expands our understanding of nucleic acid function and genetic information flow. 🧬
Read more: newshub.sustech.edu.cn/en/?p…
Cell Host & Microbe retweeted
From gut microbiota to cancer immunotherapy.
New research highlights how Akkermansia muciniphila may help overcome resistance to anti-PD-1 therapy in colorectal cancer.
An encouraging direction for microbiome-based approaches, with clinical evidence still at an early stage.
Akkermansia enhances anti-PD-1 efficacy
A. muciniphila attenuates macrophage efferocytosis to overcome PD-1 resistance in microsatellite-stable colorectal cancer (MSS CRC). Phase 1 trial supports microbiome modulation to improve immunotherapy in MSS CRC
cell.com/cell-host-microbe/f…
Weekend revisit!
VIBRANT: Phase 1 trial of multi-strain L. crispatus for BV
Women w/bacterial vaginosis receiving multi-strain vaginal L. crispatus live biotherapeutic 3–7d post antibiotics showed vaginal colonization up to 12 wks, reducing recurrent BV
cell.com/cell-host-microbe/a…
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Microbial-epigenetic-circadian axis orchestrates nutrient absorption
Microbial inositol phosphates translate feeding time into diurnal rhythms via HDAC3, activating nutrient absorption--promoting growth during undernutrition & obesity upon overnutrition
cell.com/cell-host-microbe/f…
Phage small RNA mimics chimeric guide to inhibit CRISPR-Cas9
rAcrIIA1 is phage-encoded chimeric crRNA-tracrRNA mimic that blocks Cas9 guide loading & DNA interference. This reprogrammable RNA guide enables genome editing, gene silencing & diagnostics
cell.com/cell-host-microbe/a…
Discovering phage defense systems through modularity networks
Modular organization of bacterial immune systems is used to ID phage defense systems. 3 systems in P. aeruginosa reveal strategies against jumbo phages & RM-like system w/additional components
cell.com/cell-host-microbe/f…
