Here's my conversation with Andrew Scull, all about psychiatry, its long history from Freud/Jung to today, including asylums, icepick lobotomies, electroshock therapy, antidepressants, antipsychotics, and some horrific treatments that were considered mainstream where doctors injected patients with malaria, induced insulin comas, and pulled out their teeth, all in the name of curing madness. There are a lot of lessons to learn from history here. One of the most important for me is just how incredibly complex the human mind is, and how hard the task is of understanding & treating the nearly infinite ways it can stumble/faulter. Humans are amazing. In part, because our minds are such a damn complicated mess. It's here on X in full and is up everywhere else (see comment). Timestamps: 0:00 - Introduction 1:20 - Crisis in Psychiatry 30:58 - Categories of Mental Illness 38:17 - Asylums, Eugenics, and the Nazis 50:23 - The Ice Pick Lobotomy 56:36 - Malaria "Cure" for Syphilis 1:14:52 - Insulin Coma Therapy 1:22:44 - Electroconvulsive Therapy (ECT) 1:42:13 - One Flew Over the Cuckoo's Nest 1:59:45 - Freud and Psychoanalysis 2:29:40 - WWII and Cognitive behavioral therapy (CBT) 2:50:14 - Antipsychotics 3:13:35 - Antidepressants 3:26:29 - Future of Psychiatry

Sep 17, 2026 · 12:55 AM UTC

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Here's the links for my conversation with Andrew Scull: YouTube: youtube.com/watch?v=s7d2d8Fh… Spotify: open.spotify.com/show/2MAi0B… Podcast: lexfridman.com/podcast
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And the fact that they still believe in IQ? That’s right up there with all the other nonsense.
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The history is a powerful reminder that humility has to come before certainty when we deal with the mind.
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My great uncle used to say, "I'd rather have a bottle in front of me than a frontal lobotomy." Old timer phrases
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We haven’t came very far, have we?
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It’s frightening how human naïveté, excessive confidence, and desperation to find a cure can lead to such cruelty — injuring and killing so many people in the search for a solution. A brutal lesson in via negativa: some errors only became obvious after they harmed people, leaving behind hard-won knowledge for future generations.
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I will check this out. My dad had a history of paranoia - it seems to have been more nurture than nature but he was a great man who provided for his family until his illness got hold of him. We all love him dearly. He never hurt anyone. He did find some peace in his last years once he decided to “do what they want” and go back to his psychiatrist where, once he got back on his meds, he understood that he needed them. Unfortunately, the meds need to be constantly adjusted or changed outright b/c, when they work, the same dose or even med, does not always work as effectively over time. One thing I can say is that antipsychotics should not be administered through Telehealth. That said, what about people that cannot afford the many sessions of a psychiatrist? I have no easy answer, as all solutions seem to get gamed and abused. But I will say definitively from personal experience that they can work when carefully and appropriately administered, but need to be constantly monitored and adjusted. I thank psychiatry for the ten years of relative peace it gave my father (and our family), before he passed away.
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Yikes! Can’t wait to listen to this one.
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"Sorry babe, not tonight. Lex just dropped a new podcast!"
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Wild to think what 'cutting-edge' treatments from today will look absolutely barbaric in 100 years. History's a humbling mirror.
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Hi Lex, for completeness: anti psychotics are LD-50 test proven toxic substances e.g Zyprexa is a poison, see PUBCHEM pubchem.ncbi.nlm.nih.gov/com… Combine this with *forced* treatment laws governments are mass killing patients. otpcr.rtfd.io #ggz !!
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The whole profession has done more harm than good. Tear it all down and prosecute.
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I will watch, for sure! Thank You!
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What I find interesting is his description of schizophrenia among other things because dementia could look similar to it and manifest similar symptoms for completely different reasons.
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How depressing! Perhaps you should have worn a brighter colour for this one.
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Also, I’d like to add with regard to schizophrenia, that someone who is or has been a victim of organized crime, criminal abuse of authority, national or transnational repression, cognitive or psychological warfare, sex or drug trafficking, political abuse could develop symptoms
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We’re only given a lil spark of madness… to ever lose it. 😏
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Interesting so far. The only thing is that he made it seem like NIMH under Insel did extensive research into biological origins. They did not. They exclusively focused on genetics. According to Dr. Fuller Torrey: “All they have found so far are risk genes which don’t cause disease but may make it worse once you get it. All diseases have dozens or even hundreds of risk genes but very few diseases such as Huntington’s disease have causal genes. My paper argues that 25 years of research by NIMH has found no causal genes and therefore NIMH should spend more of their resources looking for non-genetics causes, such as infectious agents and immune disorders.” sciencedirect.com/science/ar…
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Horror processed. Wonder manufactured. Mess remains. 💀
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Before I commit 3+ hours, can you say that TDS is covered? This phenomenon showed up with massive numbers and appears to be so persistent as to be considered incurable. Seeking answers about how this happened.
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I'm looking forward to listening to this podcast. My sister studied psychology and we used to have conversations about it. I studied sociology because I recognize that most issues that an individual is struggling with psychologically happens to a large number of people and I wanted to understand what is happening in society to cause these problems. Personally I'm extremely empathetic, emotional, and passionate. I have CPTSD. It's a miracle by the grace of God that is all I have and my heart only chooses love and light after what they did to my babies.
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How do you find the guests for your podcast? I feel overwhelmed by the possibilities.
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The historical framing is valuable because it shows how institutional consensus can normalize harmful practice. A useful parallel for modern psychiatry is making uncertainty and treatment outcomes visible to patients, not just experts.
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Dear Lex, Could you please add a Russian audio track to your latest podcasts on YouTube? Thank you very much in advance!
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Fantastic episode about psychiatry and its Hx, @lexfridman ... there is a documentary on the era of closure of institutions in US, it called something like From Back Wards to Back Streets a really fascinating acount of the events shot in (?)80s
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mess being messy bc it's hard to comprehend how all its complexities work together to create something so amazing and efficient at 20 watts
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The gap between what sounds mainstream and what is actually evidence-backed is where the hard work starts. Good conversation to put that distinction back on the table.
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This evil definitely exists today and is in full swing. This is one of the causes of mass insanity in the streets of America. If you, as an "untrained" person were to periodically interview (simply talk and take notes) one of these unfortunate street people as their "help" progressed, you would plainly see them getting much worse. The "professionals" imagine this same person as getting "better" or "improving" as they descend into a state where they can no longer hold a conversation, let alone hold a job. This "product" (which is VERY expensive to the taxpayers) is plainly visible to all America, at this point. So it is NOT different than 50 or 100 years ago. The evidence is ALL AROUND US. These people who cannot hold a conversation have been BRUTALIZED. Not helped. By the way, not everyone's mind is a complex mess. They just say that to explain away the fact that they are unable to bring about improvement. (Ask Elon Musk about an "expert" bridge builder who can't build a bridge that doesn't collapse.)
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‘The Snake Pit’ eek. 😥 the experiments that were (and still are) done on people for the sake of science is a travesty.
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@elonmusk The so called cure for depression/PTSD rhetoric related to ketamine, psychedelics, psilocybin, is overblown; that doesn’t keep curious, open minded confused or badly influenced children and young adults from experimenting, finding out the results without documentation
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@elonmusk Of course you don’t want to do anything illegal, rebellious, unsafe, that you’re not supposed to do but if you have PTSD flash backs, triggers, ever did have them, these things just so happen to be around, you just so happen to be in a situation where it’s possible…
Replying to @lexfridman
@elonmusk The so called cure for depression/PTSD rhetoric related to ketamine, psychedelics, psilocybin, is overblown; that doesn’t keep curious, open minded confused or badly influenced children and young adults from experimenting, finding out the results without documentation
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Lex I love your interviews. You bring a higher standard to your work and it shows. Keep up the great work. Thank you for your time.
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The historical pattern is a useful warning for AI: tools can move from experimental to routine before society has good evidence of harm. What review standard would you want before a high impact system reaches millions?
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At least someone is interviewing intelligent people maybe. Now I have to do homework and find out. Based off of the times listed, it’s worth it. Did anyone mention Oliver Saccs?
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And “these people hVw lost their humanity because their brains were defective”, doesn’t account for iatrogenic harm, damage inflicted on the client or patient from the practitioner” and “inserting yourself into the persons memories”…
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