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Joined May 2009
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Today, November 11th, marks what would have been our daughter Sybil’s 8th birthday.
It has been nearly 3 years since she passed, and not a day goes by without thinking of her and missing her smile, her curls, her bright light. It is emotional to reflect on all that has transpired with our family since her passing: Bnei Mitzvah, starting high school, new friends, new chapters.
Over the past three years, we’ve focused on family, processing our grief, and reconnecting with our community. After some time and space, we re-engaged with the research community to figure out how we could make an impact toward a cure for DIPG. Thanks to your generosity and our match, we’ve raised $2.9M+ for the Sybil Sugarman Memorial Fund to date. We were excited to announce our first grant in August: $1.45M over two years to support a joint collaboration between UCSF, Stanford, and Dana-Farber/Harvard. Together, the researchers will design and test antisense oligonucleotides (ASOs), short strands of genetic medicine that can be programmed to target and switch off the genetic messages that help drive DIPG, and develop ways to deliver them safely into the brain.
This is a high-risk, high-reward effort. The funding is intended to open up an area of research that has not yet attracted meaningful capital and has breakthrough potential. The approach mirrors seed investing: identify exceptional teams and bold ideas early; fund the key experiments when little or no other capital is available; and use proof points to attract the follow-on funding needed to carry the work forward. We believe this is where our capital can have the most leverage, and the greatest chance of outsized impact.
As we look ahead, we aim to raise awareness and funds for DIPG research and remain strongly committed to a cure for families dealing with this diagnosis. We’ll reach out annually on Sybil’s birthday in November to take a moment to remember her, her sparkle, sass, and the beautiful, happy memories we had with her.
As always, thank you for the many ways you have shown our family support, love, and kindness. We truly appreciate it - words cannot express our gratitude.
We humbly ask you to consider a donation to The Sybil Sugarman Memorial Fund today, in honor of her 8th birthday. We will continue to match your donations.
sybilsugarman.org/
All our Love,
Chloe & Mark Sugarman
I have been investing in startups for 30 years. @sendcutsend and @jimbelosic are the most customer-obsessed and the most customer love of any businesses I have invested in. @jimbelosic is a legend in the making, and I have learned so much from him as a board member and investor at @sendcutsend for the past five years. It's a pleasure collaborating with @sandykory. Excited to welcome @sequoia, @andrew__reed, @paradigm, and @matthuang to the team!
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Today, November 11th, marks what would be our daughter Sybil's 7th birthday. It has been nearly 2 years since she passed and not a day goes by without thinking of her and missing her smile, her curls, her bright light.
We’ve spent the past two years focusing on family, processing our grief, and reconnecting with our community. After some time and space, we began re-engaging with the research community in May and traveled as a family to our first DIPG conference in Ann Arbor. It felt meaningful to spend time with doctors and scientists who are working tirelessly on research and clinical trials to find a cure for DIPG. While at the conference, we met other families who have lost a child to DIPG and although it was difficult to hear their stories, we were grateful to spend time with families who had been through a journey similar to ours.
Thanks to your generosity and our 1:1 match, we’ve raised $2.56M for the Sybil Sugarman Memorial Fund to date. We’ve been in dialogue with several research institutions, speaking with experts in DIPG and the broader cancer research, immunotherapy, and drug discovery fields. We plan to make an initial donation to UCSF, where Sybil was treated, in honor of her birthday this month. Finding a cure is complicated and will likely require interdisciplinary collaboration and solutions. We plan to make initial commitments, get to know the teams and spaces, and decide where it makes the most sense to invest more heavily.
As we look ahead, we aim to raise awareness and funds for DIPG research and remain strongly committed to a cure for families dealing with this diagnosis. We’ll reach out annually around Sybil’s birthday in November to provide an update on our family, share memories of Sybil, and ask you to join us in donating to her fund.
As always, we thank you for the many ways in which you have shown our family support, love, and kindness. It is truly appreciated and words cannot express our gratitude to you.
Please join us in creating a legacy for Sybil by working together to find a cure for DIPG. Kindly consider a donation to The Sybil Sugarman Memorial Fund(link below in comments) today, in honor of her 7th birthday. We will continue to match your donations.
All our Love,
Chloe & Mark Sugarman
sybilsugarman.org/
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Direct link to Sybil Sugarman Memorial Fund: sybilsugarman.org/memorial-f…
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