VP Hematology (TIME) @TempusAI #PrecisionMedicine #mmsm #lymsm #MDSsm #leusm #CCC19 @COVID19nCCC @ASCO COI: https://xitter.twitterapi.xyz/t.co/A6GQmWYvau
Milwaukee, WI
Joined September 2010
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Whole-genome sequencing (WGS) identifies clinically relevant alterations in Myelodysplastic Syndromes (MDS) lacking detectable mutations by standard-of-care testing [Sun, Dec 13, 2026] @AlexBataller et al @garciamanero #ASH26 Abs 3835
onlineprogram.hematology.org… #MDSsm #leusm #genome
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Out now in @LeukemiaJnl!
Has survival in Waldenström macroglobulinemia actually improved in the modern treatment era?
In our new study of 1,020 patients with active WM over two decades, the answer depends on how survival is measured and on patient age.
nature.com/articles/s41375-0…
@Myeloma_mSMART @MyelomaDrKapoor @VincentRK
@myelomaMD @jonaspaludo
@JithmaA
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Can you prevent small cell transformation in high risk EGFR mutant NSCLC with osimertinib + platinum/etoposide? No. Prospective trial with high response rate, but also high rate of transformation.
By Helena Yu and MSK colleagues
published in @ScienceTM science.org/doi/10.1126/scit…
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Evolutionary dynamics in the years preceding acute myeloid leukaemia [Nov 11, 2026] @carolinewatson et al. @jrblundell @Nature nature.com/articles/s41586-0… #AMLsm #MDSsm #leusm #camoldx
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How I manage patients with unexplained cytopenia [Apr 10, 2025] Malcovati & Cazzola @BloodPortfolio ashpublications.org/blood/ar… #camoldx #PrecisionMedicine
#EAonc EAA242 - Phase Ib/II Fixed Duration Study of Teclistamab/Pomalidomide (TP) vs Carfilzomib/Pomalidomide/Dex (KPd) in Early Relapse of Multiple Myeloma [Jul 16, 2026 activation] @JanakiramMurali @AjayNookaMD @natashaedwin ecog-acrin.org/clinical-tria… #NCT0746380 #mmsm @eaonc
#EAonc EAA173 - Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM) - PI: @NatalieCal51870 ow.ly/9Z2o30oEn9T
Activated: Apr 30, 2019 #mmsm @eaonc #NCT03937635 @VincentRK
PrE1005 - Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone [Bel-VRd vs DVRd) for Newly Diagnosed Multiple Myeloma [NDMM] PI = @myelomaMD clinicaltrials.gov/study/NCT… #NCT07285239 #mmsm @eaonc
Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma - ENDURANCE [Jul 15, 2026] @myelomaMD et al. @VincentRK @NEJM
nejm.org/doi/full/10.1056/NE… #NCT01863550 #mmsm @eaonc E1A11
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EAA241 - Ph 2 RCT Dara-Bor-Dex vs Cy-Bor-Dex in the treatment of Newly Diagnosed Multiple Myeloma with Light Chain Cast Nephropathy (LCCN) [Study activated 8/11/25] @keruakous
clinicaltrials.gov/study/NCT… #NCT07085728 #mmsm @eaonc
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#EAOnc EQUATE EAA181 Effective Quadruplet Utilization After Tx Evaluation: Ph3 RCT NDMM Not Intended for Early ASCT [v.01/29/26 Add 4] PI= @myelomaMD ow.ly/aVr250BZ0dw #NCT04566328 #mmMRD #mmsm @eaonc @VincentRK @LynneWagnerPhD @mtmdphd
.@SWOG S2213 Ph3 RCT Dara-VC Induction Followed by ASCT or Dara-VCD Consolidation & Daratumumab Maintenance in Pts w/ Newly Diagnosed AL Amyloidosis [Activated: 12/1/23] swog.org/clinical-trials/s22… #mmsm #bmtsm
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Feasibility of clinical grade whole-genome sequencing [WGS] for comprehensive risk stratification and therapeutic target profiling in multiple myeloma [Sun, Dec 13, 2026] Kesaraju et al. #ASH26 Abs 4066
onlineprogram.hematology.org… #mmsm #cagenome #PrecisionMedicine @washumedicine
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Sustained disease remission with reduced-intensity allogeneic hematopoietic cell transplant for VEXAS syndrome [Nov 10, 2026] Patel et al. @emmamgroarke @Hemasphere_EHA onlinelibrary.wiley.com/doi/… #bmtsm #AMLsm #leusm
#Myeloma Paper of the Day: Patients w/ #amyloidosis & implanted cardioverter defibrillators (mean follow-up of 4.9 yrs) have high rates of mortality w/ similar outcomes for AL & ATTR, and also high rates of inappropriate shocks for both AL and TTR: pubmed.ncbi.nlm.nih.gov/4298…. #alsm
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Enhanced bone marrow Tryptophan–Kynurenine metabolism differentiates monoclonal gammopathy of undetermined significance [MGUS] from multiple myeloma [Sun, Dec 13, 2026] Chawla et al. @MayoCancerCare #ASH26 Abs 3924 onlineprogram.hematology.org… #mmsm #ImmunoOnc #IDonc #caxtx
Prevent infections with BCMA-directed bispecifics. Simple:
Think BALI #mmsm @MyelomaTeacher
B- actrim M, W, F
A- cyclovir 4ever
L- evofloxacin on month 1
I- VIg moonthly from C2D1
Data in the link
onlineprogram.hematology.org…
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Anti-infective vaccination strategies in patients with haematological malignancies or solid tumours: updated guideline of the Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology [Apr 2026] @MellinghoffSC et al. on behalf of the German Society of Hematology and Medical Oncology Infectious Diseases Working Group (AGIHO)
thelancet.com/journals/lanon… #IDonc #hemeonc
Cancer #ClinicalTrials Eligibility & Therapy Modifications for Individuals w/ Duffy Null–Associated Neutrophil Count [DANC] [Sep 11, 2024] Hibbs et al. @JAMANetworkOpen
jamanetwork.com/journals/jam…
@ASHClinicalNews Commentary: ashpublications.org/ashclini… #mmsm
