
Designer, inventor, angel investor. Finding the element that secretly governs the whole. Writing something new. Host of @firstofkind • https://xitter.twitterapi.xyz/t.co/CQ3aRhF5gk
Silicon Valley
Joined July 2007
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- Following11.2K
- Followers126K
- Likes63.5K
Bees make honey. Bees make hives.
What else could bees make? keeperfable.com/
Soleio retweeted
There are basically two kinds of companies to build right now.
1. Diffusion of AI
This is the "vertical SaaS" of today. There are a bunch of different models for it (FDE company, rollup, horizontal product) but ultimately it all boils down to the same thing: get AI diffused very close to where the work is being done.
Profound, Cognition, Harvey etc. A lot of great companies will get built here.
2. Frontier of AI
This is where the really interesting action is. Use AI to accelerate scientific progress, then build products from that progress.
It is a harder category to see. But we are seeing a lot more of it at @spc:
- Externa is adding hundreds of new chemical building blocks to proteins, so you can engineer a drug to match the disease instead of settling for what nature gave you.
- Epana Bio is using genomics and AI to design autoimmune therapies that go after the cellular origin of the disease.
- VenomicsAI is doing AI-accelerated drug discovery from venoms.
- Equivariant is doing multi-physics modeling for the semiconductor industry.
(There are always picks-and-shovels for AI as well. Lots of amazing companies in that category.)
Category 2 is not well understood or much talked about externally. It should be because I think that is where the vast majority of model driven returns will come from.
Strong Hire
.@tomjohndesign is pushing the limits of what it means to be a designer as far as anyone rn
not only did he build one of the wildest personal sites of 2026... his journey led him to create an entirely new product that is pretty mind-blowing
he shares the full behind-the-scenes in this week's episode 👇
youtube.com/watch?v=6j0S1-Qg…
the whole thing sparks a lot of questions around what it actually means to be a designer nowadays
really interesting discussion and I hope you enjoy it as much as I did :)
Soleio retweeted
Bot 1.0 is out. Our goal for this release was to make Bots a much more useful part of your team.
Some new things we're excited about:
- Bots can now join Zoom, Google Meet, and more. You can ask Bot questions in meetings and even assign it action items. We have ours taking standup notes every day in our shared Google Doc and doing background research on discussion themes. Soon, you'll be able to talk back and forth with it live in a meeting.
- A new interface for managing your Bots. You can see and steer their responsibilities, what they're learning, and their impact. It's impossible to build trust in an AI teammate if it's a black box, so it should proactively flag when it's blocked or confused, take and learn from feedback across the company, and be able to succinctly summarize its contributions.
- Better collaboration in Slack and Teams. Bots are more ambiently aware, carry context across conversations, and learn from your team over time. In our Slack, we regularly see threads between members of our team and multiple Bots, handing off work, context, and decisions. Bots should intuit your company's customs and how work gets done, not just execute on the specific tasks they're given.
There is no way I could juggle my full-time work as an investor alongside my spirited side quests with @firstofkind and @GeometryofLuck if not for @bot
It has truly altered my expectations for how AI will diffuse through the broader economy
Congrats to the team on GA!
Introducing Grok Bot 1.0. AI teammates that work alongside your whole team.
Share Bots, collaborate with them in Slack and Teams, invite them to meetings, and watch them learn and become more helpful.
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bots are everywhere!! in our slacks, in our meetings, doing the tedium, taking work off our plates and honestly, making work more... fun?
shout-outs to @tylr and @johnbai for their work on this!
Soleio retweeted
The only thing between you and success is being cringe.
“Just get over yourself. Nobody actually cares.” @dbabbs, the CTO and cofounder of @profound, on why you should go start the company before you look back and wish you had.
Dylan Babbs tried 12 to 15 ideas before Profound. The one that worked took three days.
Season 3, Episode 4, Part 1 is here:
LIVE from SPC – @dbabbs joins @soleio before a live audience at @spc, where @profound got its start. Now available on 𝕏, YouTube, and Instagram
Part 2 drops Thursday.
Powered by @framer @noondesign @bot @tryramp @vercel @meetgranola @profound
Hosted by @soleio and coproduced with @Room3NYC
Vmax is building Campaign, a platform for RL task generation using self-play.
We worked with them to teach agents to use the Modal SDK, translating Python code into working Modal workloads by generating tasks that target their failure modes.
Modal's elastic compute lets them run and check solutions, from GPU calculations to inference endpoints that reuse state across requests.
1/ As a teaser for Campaign, Vmax’s infrastructure for automated task generation, we are sharing work we did earlier this year for @modal using self-play to generate tasks that target weaknesses of models when using the Modal-SDK.
This has fundamentally changed how our team works.
We’re moving from everyone having their own AI assistant to entire teams working with the same bots. Really excited to finally get this into people’s hands.
Try it out and let us know what you think!
Soleio retweeted
Everyone in tech is talking about taste. @dbabbs thinks it’s simpler than that.
“With visual design, you don’t have to be that creative. I think you need to understand what looks good. And then just put in the reps to really nail it.”
The CTO and cofounder of @profound, recorded live at @SPC.
Dylan Babbs tried 12 to 15 ideas before Profound. The one that worked took three days.
Season 3, Episode 4, Part 1 is here:
LIVE from SPC – @dbabbs joins @soleio before a live audience at @spc, where @profound got its start. Now available on 𝕏, YouTube, and Instagram
Part 2 drops Thursday.
Powered by @framer @noondesign @bot @tryramp @vercel @meetgranola @profound
Hosted by @soleio and coproduced with @Room3NYC
The future of software is stateful, multiplayer, and collaborative.
The team environment is the ultimate harness, the dining room table where we eat and talk and laugh together.
Your agents can now coordinate with your teammates’ agents.
Projects has been rebuilt for multiplayer: every teammate and their agents can now work together in one unified workspace.
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Wonderfully personal. Wonderfully earnest. Wonderfully real.
Made an interactive story about what war in the Marine Corps taught me about creating.
tomgeoco.com/geronimos-garde…
Soleio retweeted
Dunno about you, but I hop between Claude, ChatGPT, Grokbot, Cursor, etc every day. No longer do i have to rely on their memories, or teach them what I know.
Plug in Granola and give them an always-up-to date picture of you to help them work better
The Big Labs are hoping that once you set up your agent, it’ll be too painful to switch. That’s why they let you connect apps via MCP, but don’t offer an MCP (even though they invented it 🤔).
We’re all better off when we’re not locked-in to one agent. Check out your agent brief, they are surprisingly good!
A marquee Tuesday:
➀ @dbabbs episode for @firstofkind
➁ @GeometryofLuck talk
➂ @alexcornell design chat @SPC
Productive day. More soon.
Such a treat to speak publicly about a topic I hold so dear on American soil for the first time. In San Francisco, no less! Thank you @thecultureslop and @tiatplace for hosting.
Come hear from @soleio @firstofkind on The Geometry of Luck.
Culture Slop Live! is made up of five talks from people shaping how tech feels, each designed to expand and challenge how you think about what you're creating and how you're creating it.
🗓️ Nov 10 · @tiatplace · presented by @airHQ
🎟️ Apply for a ticket below
And grateful to @alexcornell for sharing a wide range of incredible insights behind the creation of @muse and its myriad design principles
Next up: @johnbai is @SPC Design Chat XI
Two weeks in a row in this audience @spc . Worth it both times.
@iansilber and @alexcornell brought real stories, advice, and hot takes. I left energized to be a designer right now.
Thank you @soleio for everything you do for the design community.
Bonus, meeting one of my design heroes @camworboys
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Soleio retweeted
We made Agent Briefs so the agents you use are kept up to date with all your work context. It pulls from your meeting notes, calendar, etc so it’s always on point.
You can finally tell your agent "you're so right"
The Big Labs are hoping that once you set up your agent, it’ll be too painful to switch. That’s why they let you connect apps via MCP, but don’t offer an MCP (even though they invented it 🤔).
We’re all better off when we’re not locked-in to one agent. Check out your agent brief, they are surprisingly good!
Soleio retweeted
Town just made The Information's 50 Most Promising Startups. It's humbling to see us get this recognition.
This is a list that's included startups like Cursor and Grafana before they broke out. I think we're in good company.
Their write-up talks about how our power users love using their Townies (their AI assistants) for communication-heavy roles like sales or investing. I'd go a step further and say any role that has a lot of work that isn't particularly hard is a perfect role for working with a Townie.
This type of work is everywhere, and we're building to make sure Townies take care of that stuff for you.
Thanks to @theinformation for the recognition, and thanks to all our customers for helping get us to where we are today.
I use Granola for everything - work, my side projects, writing ideas, doctor visits, personal training, etc. I know @meetgranola is the tool that knows me best.
SO glad this is finally out and we can talk about it publicly. Give your Agent Brief a spin!
The Big Labs are hoping that once you set up your agent, it’ll be too painful to switch. That’s why they let you connect apps via MCP, but don’t offer an MCP (even though they invented it 🤔).
We’re all better off when we’re not locked-in to one agent. Check out your agent brief, they are surprisingly good!
Soleio retweeted
the best teams 🚢 🚢🚢! nobody higher velocity than @cjpedregal & @meetgranola
The Big Labs are hoping that once you set up your agent, it’ll be too painful to switch. That’s why they let you connect apps via MCP, but don’t offer an MCP (even though they invented it 🤔).
We’re all better off when we’re not locked-in to one agent. Check out your agent brief, they are surprisingly good!
granola is the only place that has the full picture of everything i'm working on, who i'm collaborating with, and exactly what's top of mind for me in those projects + relationships. now all your bots can get that knowledge too :)
monumental ship by @sjmog1 @JoBarrow @samstphenson and team
The Big Labs are hoping that once you set up your agent, it’ll be too painful to switch. That’s why they let you connect apps via MCP, but don’t offer an MCP (even though they invented it 🤔).
We’re all better off when we’re not locked-in to one agent. Check out your agent brief, they are surprisingly good!
Soleio retweeted
The Big Labs are hoping that once you set up your agent, it’ll be too painful to switch. That’s why they let you connect apps via MCP, but don’t offer an MCP (even though they invented it 🤔).
We’re all better off when we’re not locked-in to one agent. Check out your agent brief, they are surprisingly good!
Introducing Agent Briefs. Every night, Granola crunches everything it knows about you and summarizes it for your agents: priorities, habits, relationships - even how you communicate.
This way, all agents have your best, most up-to-date context.
See what yours says below 👇
Claude: grano.la/brief-claude
ChatGPT: grano.la/brief-chatgpt
Soleio retweeted
Introducing Agent Briefs. Every night, Granola crunches everything it knows about you and summarizes it for your agents: priorities, habits, relationships - even how you communicate.
This way, all agents have your best, most up-to-date context.
See what yours says below 👇
Claude: grano.la/brief-claude
ChatGPT: grano.la/brief-chatgpt


































