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National Cancer Institute

@theNCI

The U.S. government’s agency for cancer research. Part of @NIH. Engagement ≠ endorsement. Questions about cancer? Reach us here: https://xitter.twitterapi.xyz/t.co/yQAi9x4Obg

 Bethesda, MD
cancer.gov
Joined May 2009
  • Tweets25.4K
  • Following4.2K
  • Followers226K
More men with low-risk prostate cancer are holding off on radiation or surgery, a new study found. In NCI cancer registry data, 83.4% received neither treatment within a year of diagnosis in 2023, up from 33.6% in 2010. The findings suggest progress toward avoiding unnecessary treatment. Read the study: doi.org/10.1002/cncr.70603
Prostate cancer; drawing shows cancer in one side of the prostate. Also shown are the bladder, rectum, and urethra.\n\nProstate cancer forms in the tissues of the prostate (a gland in the male reproductive system that lies just below the bladder and in front of the rectum). Image Credit: Therese Winslow

ALT Prostate cancer; drawing shows cancer in one side of the prostate. Also shown are the bladder, rectum, and urethra.\n\nProstate cancer forms in the tissues of the prostate (a gland in the male reproductive system that lies just below the bladder and in front of the rectum). Image Credit: Therese Winslow

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Research toward a functional cure for #HIV is drawing on T-cell engineering, antibody discovery, and lessons from cancer #immunotherapy. At a recent Frederick National Laboratory seminar, researchers shared their findings and next steps. go.nih.gov/GsPP3St
Three-dimensional structure of HIV infected (blue, green) and uninfected (brown, purple) T cells interacting. One cell (brown) has wrapped an extension around its uninfected neighbor (purple) to reach an infected cell (blue). Data from focused ion beam scanning electron microscopy (FIB-SEM).

ALT Three-dimensional structure of HIV infected (blue, green) and uninfected (brown, purple) T cells interacting. One cell (brown) has wrapped an extension around its uninfected neighbor (purple) to reach an infected cell (blue). Data from focused ion beam scanning electron microscopy (FIB-SEM).

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Our Patient-Derived Models Repository (NCI-PDMR) has released its first publicly available tissue microarray panel from pancreatic adenocarcinoma patient-derived xenografts, allowing researchers to screen protein biomarkers across 60 tumor models. go.nih.gov/L4yPEVJ
Photograph of a TMA slide and a highly magnified sample of PDX tumor.

ALT Photograph of a TMA slide and a highly magnified sample of PDX tumor.

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Meet Bart Vanhaesebroeck, whose REWIRE-CAN team is exploring whether pushing cancer’s growth signals beyond their tolerated limits could make colorectal cancer cells vulnerable. Watch what motivates his work. go.nih.gov/3G8zV4V @CancerGrand
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Delivering cancer-killing drugs directly to tumor cells: NCI researchers developed antibody-drug conjugates that shrank #rhabdomyosarcoma tumors in mice. Explore the findings and the next steps toward clinical testing: go.nih.gov/ZQnHmpB
An illustration of an antibody target closing in on a rhabdomyosarcoma cell.

ALT An illustration of an antibody target closing in on a rhabdomyosarcoma cell.

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A natural RNA modification could help synthetic mRNA make proteins more efficiently and accurately. NCI-led research in cells and mice points to possibilities for future mRNA vaccines and therapies. Explore the findings: go.nih.gov/fwpmhRw
A side by side comparison diagram showing how mRNA therapies work to make specific proteins currently and how a naturally occuring modification could produce the same outputs more efficiently.

ALT A side by side comparison diagram showing how mRNA therapies work to make specific proteins currently and how a naturally occuring modification could produce the same outputs more efficiently.

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At the next NCI Global Cancer Research & Control Seminar, learn how Dr. Kristin Schroeder & Dr. Erica Sanga are advancing #ChildhoodCancer care in Tanzania with a multimedia caregiver education program. Dec 10, 10:00-11:00am ET | CME available. Register: go.nih.gov/9bGLqAN
A promotional graphic sharing details about NCI's Global Cancer Research & Control Seminar, \"Building Caregiver Education Together: A multimedia approach to childhood cancer care in Tanania\" presented by Dr. Kristin Schroeder & Dr. Erica Sanga. Taking place, virtually, on Dec 10, 10:00-11:00am ET. CME available.

ALT A promotional graphic sharing details about NCI's Global Cancer Research & Control Seminar, \"Building Caregiver Education Together: A multimedia approach to childhood cancer care in Tanania\" presented by Dr. Kristin Schroeder & Dr. Erica Sanga. Taking place, virtually, on Dec 10, 10:00-11:00am ET. CME available.

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For Paula, being able to enjoy everyday moments with her family meant so much. Taking her newborn for a walk. Sitting around the dinner table with family. Being present in her own life. Her experience offers a personal perspective on an important focus of cancer research: quality of life. Watch her reflect on daily life while participating in a clinical trial.
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Understanding cancer risk means looking beyond genetics alone. Exposome research helps us measure how environmental factors—from air quality to diet to stress—shape health across a lifetime, creating new opportunities for prevention. go.nih.gov/aTtmsGu @NIH

Understanding the exposome

The world around us influences our health in countless ways. New tools and approaches are helping scientists measure our environmental exposures—both good and bad—on a large scale in the hopes of...

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NCI researchers uncovered why a widely used #leukemia drug can cause movement and balance problems in some patients. Understanding treatment-related side effects is essential to improving cancer care, quality of life, and outcomes for patients. go.nih.gov/wWjR0JP
Acute myeloid leukemia

ALT Acute myeloid leukemia

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Understanding how cells can heritably reprogram gene expression without mutating their DNA may open new strategies to prevent tumor cells from acquiring resistance to therapy. See our most recent research on treatment resistance: go.nih.gov/qw3WugR
This diagram shows how environmental stressors like antifungal drugs or high temperatures can trigger a molecular chain reaction inside fission yeast cells, which share many of the same pathways as human cells.\n\nExternal signals funnel through two internal communication networks into a molecular dimmer switch called the heterochromatin heritability regulatory hub, or HRH. When stress turns the dimmer up, the HRH can drive the assembly of tightly packed DNA regions called heterochromatin, locking certain genes off. Those silencing patterns can then be passed on to daughter cells when the cell divides \u2014 no changes to the underlying DNA sequence required. Image Credit: Shiv Grewal

ALT This diagram shows how environmental stressors like antifungal drugs or high temperatures can trigger a molecular chain reaction inside fission yeast cells, which share many of the same pathways as human cells.\n\nExternal signals funnel through two internal communication networks into a molecular dimmer switch called the heterochromatin heritability regulatory hub, or HRH. When stress turns the dimmer up, the HRH can drive the assembly of tightly packed DNA regions called heterochromatin, locking certain genes off. Those silencing patterns can then be passed on to daughter cells when the cell divides \u2014 no changes to the underlying DNA sequence required. Image Credit: Shiv Grewal

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Menopausal hormone therapy does not raise the risk of developing or dying from liver cancer, according to results from two randomized trials that followed more than 27,000 postmenopausal women for nearly 24 years. The findings are from @NIH Women’s Health Initiative. Read more: go.nih.gov/l1ycc0C
A patient shows the palm of their hand while holding a variety of oral treatment while standing near a medical professional.

ALT A patient shows the palm of their hand while holding a variety of oral treatment while standing near a medical professional.

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Today’s cancer treatments are built on decades of research—and sustained support. Former @NIH and NCI Director Dr. Harold Varmus reflects on why continued investment in NCI matters and gives researchers the opportunity to pursue new ideas and improve cancer prevention and treatment.
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🧵 (1/6) Mark your calendar for these highlighted, upcoming virtual NCI events on topics including supporting caregivers, entrepreneurial training, ultra-processed foods, and more ⬇️
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Caregivers: Partners in the Journey of Cancer Survivorship 🗓️ 11/5, 1-2 p.m. ET Dr. J. Nicolas Odom will discuss the vital role caregivers play across the cancer survivorship journey and strategies for supporting caregivers and families. Register: go.nih.gov/46Lb5qv
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PRESS RELEASE: Results from an NCI clinical trial—the first to evaluate the drug invikafusp alfa (invika) in humans—indicate that the treatment may be capable of managing cancers that have rebuffed most other treatments, including standard immunotherapy go.nih.gov/7nhgD4T
White text on a green background reads, \"NCI Research News: A precision T-cell therapy stalls treatment-resistant cancers in clinical trial. National Cancer Institute.\"

ALT White text on a green background reads, \"NCI Research News: A precision T-cell therapy stalls treatment-resistant cancers in clinical trial. National Cancer Institute.\"

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The 2026–27 Lasker Clinical Research Scholars Program is now accepting applications! Ready to take the next step in your clinical research career? Learn more and apply by November 6: go.nih.gov/srT3IfN
A professional reviews content on a computer screen. Text reads, \"Your research. Your vision. Our support. Vacancy Announcement: NIH Lasker Clinical Research Scholars Program. National Cancer Institute.\"

ALT A professional reviews content on a computer screen. Text reads, \"Your research. Your vision. Our support. Vacancy Announcement: NIH Lasker Clinical Research Scholars Program. National Cancer Institute.\"

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Our Cancer Information Service (CIS) has connected people with accurate, up-to-date information about cancer research and clinical trials, prevention and screening, treatment, tissue donation, NCI programs, and more. Chat with a specialist today: livehelp.cancer.gov/
A man talking into a headset in a professional setting.

ALT A man talking into a headset in a professional setting.

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Interested in taking the next step in your cancer research career? Applications for NCI's Intramural Continuing Umbrella of Research Experiences (iCURE) program are open through November 30. iCURE provides research and career-development opportunities for eligible postbacs, grads, and postdocs. Apply: go.nih.gov/TlZnBQq
Text on a blue background reads, \"Intramural Continuing Umbrella of Research Experiences (iCURE). The iCURE program provides research opportunities, mentorship, and career development support to foster independence and drive innovation in cancer research. Positions are available for postbacs, graduate students, and postdocs. Application Deadline: November 30, 2026.\"

ALT Text on a blue background reads, \"Intramural Continuing Umbrella of Research Experiences (iCURE). The iCURE program provides research opportunities, mentorship, and career development support to foster independence and drive innovation in cancer research. Positions are available for postbacs, graduate students, and postdocs. Application Deadline: November 30, 2026.\"

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HIRING: Deputy Director, NCI Center for Global Health. This position will provide executive leadership for the global research portfolio, including advancing research capacity, implementation science, and cancer control. Apply by November 18 at go.nih.gov/cNiumsg
Text reads, \"Vacancy Announcement. Deputy Director, Center for Global Health, NCI. National Cancer Institute.\"

ALT Text reads, \"Vacancy Announcement. Deputy Director, Center for Global Health, NCI. National Cancer Institute.\"

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We join many around the world in wishing Pope Leo XIV strength and healing as he recovers.
Dr. Anthony Letai (@NCIDirector) profile pictureDr. Anthony Letai@NCIDirectorOct 14
My best wishes to @Pontifex for strength and a full recovery after his lung cancer surgery. As an oncologist, I’ve seen how a diagnosis like this affects not just the patient, but everyone around them. I am thinking of him and those caring for him.
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To learn more about lung cancer, including treatment, screening, research, and resources for patients and families, visit our lung cancer page: cancer.gov/types/lung.
Lung Cancer

Lung Cancer

The two main types of lung cancer are non-small cell lung cancer and small cell lung cancer. Smoking causes most lung cancers, but nonsmokers can also develop lung cancer. Start here to find inform...

cancer.gov
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