Alfredo Guillén-del-Castillo (@_AlfredoGuillen) header
Alfredo Guillén-del-Castillo (@_AlfredoGuillen) profile picture

Alfredo Guillén-del-Castillo

@_AlfredoGuillen

Internist #SystemicSclerosis #AutoimmuneDiseases @vallhebron @UABBarcelona | Vall d’Hebron Barcelona Hospital Campus | Universitat Autònoma de Barcelona

 Barcelona, Spain
Joined August 2020
  • Tweets472
  • Following188
  • Followers289
57Media
Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)Photo by Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
NEJM: Ianalumab for the Treatment of Patients with Sjögren’s Disease ⏩phase 3 RCTs (n=779) ⏩Monthly 300 mg improved ESSDAI at 48 weeks (−1.3/−1.0 vs placebo) ⏩No significant benefit in symptoms or ESSDAI response ⏩Similar serious adverse events nejm.org/doi/10.1056/NEJMoa2…
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
9
17
884
Hoy en el Día Mundial de la Esclerodermia 29 jun 🌻🌻🌻 Lo hemos celebrado con la I Jornada de #Esclerodermia para Pacientes del Hospital Vall d’Hebron !!! Gracias a tod@s !!! @AEEsclerodermia @vallhebron @MIVHSistemiques
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
1
7
14
850
Replying to @_AlfredoGuillen @AEEsclerodermia @vallhebron @GEAS_SEMI @SociedadSEMAIS
Excelente iniciativa! Formato coloquio 💬, espacio de conversación entre profesionales 🧑‍🏫especializados en el control de la #Esclerodermia y pacientes! @vallhebron @internavalle 🌻🌻🌻
Image from U. M. Sistèmiques. Medicina Interna H. V. d'Hebron (@MIVHSistemiques)
2
5
103
29 Junio celebramos la I Jornada de Esclerodermia para Pacientes a la @vallhebron Incluirá sesiones informativas, y espacios de conversación. 📍 Salón de actos, planta 10, Edificio General 📅 29/06/2026 🕒 15:30-19:00 h 💻 Presencial 📝 Inscripción: QR @AEEsclerodermia @cpsimeon
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
1
3
6
139
Ya falta menos para la I Jornada de Esclerodermia para Pacientes del Hospital Vall d’Hebron !!! Coincidiendo con el Día Mundial de la Esclerodermia 29 jun 🌻🌻🌻 📝 inscríbete mediante el QR 👇 @AEEsclerodermia @vallhebron @MIVHSistemiques @GEAS_SEMI @SociedadSEMAIS
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
1
1
1
74
29Juny celebrem la I Jornada d'Esclerodèrmia per a Pacients a la @vallhebron Inclourà sessions informatives, i espais de conversa. 📍 Lloc: Sala d’actes, planta 10, Edifici General 📅 Data: 29/06/2026 🕒 Hora: 15:30-19:00 h 💻 Presencial 📝 Inscripció: QR @AEEsclerodermia
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
1
5
6
359
Alfredo Guillén-del-Castillo retweeted
Reumatologia Sant Pau-Dos de Maig (@reuma_santpau) profile picture
Reumatologia Sant Pau-Dos de Maig@reuma_santpauJun 6
How do we tackle 🫀involvement in SSc @ivancastellvi breaks down the latest insights at #EULAR2026: 1️⃣ MMF should be considered upon suspicion of inflammation. 2️⃣ Therapy is recommended if symptomatic with MRI-confirmed miocarditis. 3️⃣ Treat beyond inflammation— target fibrosis
Image from Reumatologia Sant Pau-Dos de Maig (@reuma_santpau)
Image from Reumatologia Sant Pau-Dos de Maig (@reuma_santpau)
Image from Reumatologia Sant Pau-Dos de Maig (@reuma_santpau)
Image from Reumatologia Sant Pau-Dos de Maig (@reuma_santpau)
6
24
641
Alfredo Guillén-del-Castillo retweeted
Capillary.io (@CapillaryIo) profile picture
Capillary.io@CapillaryIoJun 7
Replying to @joraltron
@joraltron is sharing the latest results from #eular on behalf of the capiAMI group. Congratulations!
Image from Capillary.io (@CapillaryIo)
Image from Capillary.io (@CapillaryIo)
2
7
215
Alfredo Guillén-del-Castillo retweeted
Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli) profile picture
Autoinmunes Medicina Interna Parc Taulí@autoinMI_tauliJun 6
Delighted to participate and learn at #EULAR2026 in London, representing Hospital Parc Taulí and GEAS-SEMI through the Sarcogeas Registry. @parctauli @GEAS_SEMI_
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
Image from Autoinmunes Medicina Interna Parc Taulí (@autoinMI_tauli)
6
1
14
1,374
Alfredo Guillén-del-Castillo retweeted
Prakashini (@prakashini_) profile picture
Prakashini@prakashini_Jun 3
An insightful session on the non-pharmacological management of digital ulcers in SSc #EULAR2026
Image from Prakashini (@prakashini_)
Image from Prakashini (@prakashini_)
Image from Prakashini (@prakashini_)
Image from Prakashini (@prakashini_)
1
27
2
66
4,015
Alfredo Guillén-del-Castillo retweeted
NEJM (@NEJM) profile picture
NEJM
@NEJMJun 3
Presented at #EULAR2026: Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone. Full phase 3 REPLENISH trial results: nej.md/3PvmmMO Editorial: Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting nej.md/4dB5b5I Original Article in @NEJMEvidence: Secukinumab for Giant Cell Arteritis (phase 3 GCAptAIN trial) eviden.cc/49CLAj9 @eular_org
Chart from an article published in the New England Journal of Medicine showing results from a phase 3 trial of secukinumab in polymyalgia rheumatica. Two bar graphs depict sustained remission and complete sustained remission at week 52, comparing secukinumab, 300 mg (dark blue bars); secukinumab, 150 mg (light blue bars); and placebo (grey bars). Statistical significance is noted with P<0.001 for each comparison.

ALT Chart from an article published in the New England Journal of Medicine showing results from a phase 3 trial of secukinumab in polymyalgia rheumatica. Two bar graphs depict sustained remission and complete sustained remission at week 52, comparing secukinumab, 300 mg (dark blue bars); secukinumab, 150 mg (light blue bars); and placebo (grey bars). Statistical significance is noted with P<0.001 for each comparison.

2
67
2
172
16,182
I was very happy to participate in the annual Scleroderma Family Day at @RoyalFreeNHS, where I presented our experience of managing #SystemicSclerosis in Barcelona. Thank you to the patients from the @AAEsclerodermia for their support! @vallhebron @SclerodermaRF @GEAS_SEMI
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
Image from Alfredo Guillén-del-Castillo (@_AlfredoGuillen)
3
8
578
Alfredo Guillén-del-Castillo retweeted
ERN ReCONNET 🇪🇺 (@ern_reconnet) profile picture
ERN ReCONNET 🇪🇺@ern_reconnetMay 7
Register now for the 🆕@ern_reconnet #webinar “CAR-T Therapy in Systemic Lupus Erythematosus (SLE): Explained to the Patient” with Prof. Georg Schett, moderated by Prof. Marta Mosca and the ePAG Jeanette Andersen. 🗓️May 13th - 16 CET ✍️Registration is: rb.gy/s18q03
Image from ERN ReCONNET 🇪🇺 (@ern_reconnet)
1
1
4
516
Alfredo Guillén-del-Castillo retweeted
M. Acosta-Herrera (@illcryifiwantto) profile picture
M. Acosta-Herrera@illcryifiwanttoApr 27
Our new paper is our! Sex-specific genetic architecture in #scleroderma. Sex is a key biological variable we can't afford to ignore in biomedical research! Congrats to the team!🥳 @Inmaculada_roma @ipbln_csic
The Lancet Rheumatology (@TheLancetRheum) profile pictureThe Lancet Rheumatology@TheLancetRheumApr 24
NEW RESEARCH—Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study bit.ly/3OHY4ys Plus, linked Comment bit.ly/4e8AvJK
Image from The Lancet Rheumatology (@TheLancetRheum)
3
6
207
🧵✨ Arrenca la IV Jornada de Malalties Autoimmunes Sistèmiques del Servei de Medicina Interna! Durant la tarda anirem comentant les ponències una a una 🩺📚 amb els punts clau, novetats i reflexions més destacades. Segueix el fil 👇 #4jornadaEASMIVH
Image from U. M. Sistèmiques. Medicina Interna H. V. d'Hebron (@MIVHSistemiques)
2
2
1
6
360
Alfredo Guillén-del-Castillo retweeted
SclerodermaRF (@SclerodermaRF) profile picture
SclerodermaRF@SclerodermaRFApr 25
3 weeks to go, Sat 16th May: annual family day and 31st year anniversary of the scleroderma unit 🥳 FREE, accessible to all, no ticket required. Eternal gratitude to Dame Prof Carol Black, Prof Chris Denton and team @RoyalFreeNHS 🌟🙏 royalfreecharity.org/donate #SclerodermaFreeWorld
Image from SclerodermaRF (@SclerodermaRF)
3
4
96
Alfredo Guillén-del-Castillo retweeted
The Lancet Rheumatology (@TheLancetRheum) profile picture
The Lancet Rheumatology@TheLancetRheumApr 24
NEW RESEARCH—Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study bit.ly/3OHY4ys Plus, linked Comment bit.ly/4e8AvJK
Image from The Lancet Rheumatology (@TheLancetRheum)
4
1
10
1,015
Falta menys duna setmana! Ens hi veurem? @_AlfredoGuillen @internavalle @cpsimeon @claudiacodina7 @jaume_mt @Sociedad_SEMI
U. M. Sistèmiques. Medicina Interna H. V. d'Hebron (@MIVHSistemiques) profile pictureU. M. Sistèmiques. Medicina Interna H. V. d'Hebron@MIVHSistemiquesApr 14
Ja t'has inscrit a la IV Jornada de Malalties Sistèmiques? Aquí et deixem el link: IV Jornada de la unitat de malalties autoimmunes sistèmiques share.google/gPmpZImL0FKl8WN…
Image from U. M. Sistèmiques. Medicina Interna H. V. d'Hebron (@MIVHSistemiques)
4
6
1,431
Alfredo Guillén-del-Castillo retweeted
Inmaculada Rodríguez (@Inmaculada_roma) profile picture
Inmaculada Rodríguez@Inmaculada_romaApr 16
Excited to share our latest work about sex-dependent genetics is now available in Lancet Rheumatology!! 🙌🏻🙌🏻🥳 (doi.org/10.1016/S2665-9913(2…) Thank you to everyone who made it possible and congratulations to all the team ☺️ @illcryifiwantto
2
2
6
141
Alfredo Guillén-del-Castillo retweeted
Iago Pinal-Fernandez (@DrIagoPinal) profile picture
Iago Pinal-Fernandez@DrIagoPinalFeb 18
🧬🚨New in @medrxivpreprint: Spatial transcriptomics reveals mechanism of autoimmunity driven by internalized autoantibodies: antibody secreting cells induce antibody internalization, disrupt autoantigen function, and drive muscle damage and inflammation doi.org/10.64898/2026.02.14.…
Image from Iago Pinal-Fernandez (@DrIagoPinal)
Image from Iago Pinal-Fernandez (@DrIagoPinal)
Image from Iago Pinal-Fernandez (@DrIagoPinal)
1
12
1
21
1,908
Load more