Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
Harvard
Joined March 2012
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Breaking
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Which age clocks are worth it?
Run the same blood sample twice and some aging clocks can give answers 9 years apart. Which age tests can you trust and what should you ask before you buy one? lifespan.com/blogs/magazine/…
It’s only right to warn patients of the potential risk of sudden blindness, however unlikely
The FDA warned that GLP-1 drugs carry a potential risk for a rare but serious eye condition and required pharma companies to inform patients and doctors of the risk. statnews.com/2026/11/09/glp-…
Massive failure at Novartis to improve cardiovascular outcomes by lowering Lp(a). What went wrong? What now? Is Lp(a) useful? lifespan.com/blogs/magazine/…
It’s encouraging
Longevity industry is ripping 🔥🔥
My favorite part: Lilly and Novo are now using aging clocks as trial readouts, and patients on their drugs are reading biologically younger. Novo saw hearts up to 4 years younger vs placebo.
@TheEconomist
economist.com/business/2026/…
In a child with a genetic developmental disorder, motor movement scores rose from 20 to 60 over 25 months while taking the NAD booster NMN. This case suggests NMN may help motor development, warranting further study link.springer.com/article/10…
rafasmoonshot.com/launching-…
Despite blood lipid levels staying the same, intermittent fasting of mice reduced arterial plaque size
Macrophages were activated to clear dead cells
Interesting 🤔link.springer.com/article/10…
I feel far from wanting to get older,
Not knowing what is around the corner.
Time comes and goes, slips away,
Melting away our years.
I am waiting to change,
To be again young.
- Excerpt from The Race Against Time by V.G. Lopez, a 64-year-old poet, singer & lifelong student of human behavior
Image from this Sunday's Lifespan.com newsletter, with news about Congress and research funding, better sleep, Longevity Grok, neuroprotection, avoiding Ozempic face & approaching the Singularity
🤖 Made with AI
This is just the start. @biogerontology and I are already scoping 2.0 🙏
Longevity Grok, a.k.a. your personal longevity superintelligence (PLSI), is an open-source multi-agent workhorse designed to keep you alive & healthy for as long as possible. A collaborative effort from @InSilicoMeds & the Sinclair Lab @harvardmed. Visit longevitygrok.si
Excited to be on Lipfendra, the first oral PCSK9 inhibitor to prevent arterial plaque buildup
Dramatic reductions seen in LDL, ApoB and Lp(a)
So, what's it cost? How does it work? Is it worth it?
A study found no age-related decline in whole-blood NAD. Some trollfessors took that to mean NAD has no role in aging. Now Gardell and Baur explain why the report of the theory's death was an exaggeration 🧵 @NatMetabolism
Life’s short. Let’s fix that.
There is no application of AI and SI more impactful than Productive Longevity. Personal Longevity Superintelligence brought to you by my team and brilliant @davidasinclair and made possible with @bot . Grok Bot users get longevity superpowers - link at LongevityGrok.si
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ALS NEWS: Small molecule screen identifies SIRT1 as a key therapeutic target in ALS. SIRT1 activators hopeaphenol & SRT2104 (a SIRT1 activator with brain permeability & tolerability in humans) reduced motor neuron cell death, degeneration, and firing rates @NaturePortfolio
