Ethan Perlstein 1-to-N (@eperlste) | teapawt

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Ethan Perlstein 1-to-N

@eperlsteApr 17

I've met so many entrepreneurial rare disease parents over the years that I’ve lost count. They have moved or are moving medical mountains to save their kids and others like them. But rare parent founders get no love from institutional players. Those days are done. Science, talent and compute are no longer limiting. Priority Review Voucher alpha makes the economics work. The missing spark is access to cure capital. That's why I’m incredibly pumped to relaunch @1000cures with my cofounder @ryan_1000cures! Ryan and I teamed up to create a “YC for Rare” that unites our biotech houses with complementary expertises, experiences and networks. 1000 Cures is an accelerator for lean startups led by parents on mission to cure pediatric rare diseases. We ride at dawn. Let’s go!

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Ethan Perlstein 1-to-N retweeted

Ethan Perlstein 1-to-N

Why is TradBio so decel?

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Ethan Perlstein 1-to-N retweeted

Ethan Perlstein 1-to-N

Why does every academic sound like Reviewer 3?

Ran Blekhman@blekhman18h

Why does every AI Bio company sounds exactly like Theranos? "a CRO but really fast" (with no tech innovation, no experience in biology) sounds a lot like "a blood test but from a really small amount"

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Ethan Perlstein 1-to-N retweeted

Ethan Perlstein 1-to-N

Can we get a rare disease mom to honeypot a Big Pharma CEO so we can cure all rare genetic diseases already?

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Ethan Perlstein 1-to-N

This is what horse and buggy drivers said circa 1910

John Maraganore 🇺🇸🇬🇷🇺🇦

@JMaraganore23h

Unfortunately, there is an enormous gap in biological data. While the impact of AI will be incredible, it will sadly be a very long time before disease is a “relic of the past.”

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Ethan Perlstein 1-to-N retweeted

Why are old stories that were not even covered up all that well become sudden international and geopolitical news? The timing is suspicious, so worth asking: who benefits and why now? If Jensen, the premier champion of open models, is taken out then anyone who wants AI closed, centralized, and controlled might benefit. Why now? The midterms seem relevant. But also perhaps the upcoming IPOs.

The Wall Street Journal

Breaking: Nvidia’s board is preparing to oust CEO Jensen Huang after he had two extramarital affairs, including one with a suspected Chinese spy. on.wsj.com/4jcpr01

Image from The Wall Street Journal (@WSJ)

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Ethan Perlstein 1-to-N

stop on hating on GenXers they’ve been suffering since Reality Bites

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Ethan Perlstein 1-to-N

This is why I only conduct in-person BOD mtgs

Shocking new footage of Nvidia’s latest board meeting just leaked 💀

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Ethan Perlstein 1-to-N

🎯🎯🎯

@MichaelaThinks21h

Unironically, it is so good that biology is cool now. Everyone should be rooting for AI to cure all disease. Stop speculating about whether it will or will not happen and ask yourself what you personally can do to make it happen. Then do it

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Ethan Perlstein 1-to-N

He’s got a point..

No. Bill Clinton did not resign. Jensen Huang shouldn’t either. And the Nvidia board shouldn’t fire him. Particularly in the heat of the moment. Ride it out and ignore the journos. Clinton did. And then no one cared.

Image from Balaji (@balajis)

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Ethan Perlstein 1-to-N

Why is TradBio so decel?

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Ethan Perlstein 1-to-N

Why does every academic sound like Reviewer 3?

Ran Blekhman@blekhman18h

Why does every AI Bio company sounds exactly like Theranos? "a CRO but really fast" (with no tech innovation, no experience in biology) sounds a lot like "a blood test but from a really small amount"

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Ethan Perlstein 1-to-N retweeted

bnuoH@lcbnuoH23h

Biotech CEOs are usually so poor that they can only have regulatory Affairs.

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Ethan Perlstein 1-to-N

Can we get a rare disease mom to honeypot a Big Pharma CEO so we can cure all rare genetic diseases already?

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Ethan Perlstein 1-to-N

so is jensen’s second side dish technically a distillation?

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Ethan Perlstein 1-to-N

Kickoff reception for the @MilkenInstitute 2026 Future of Health Summit in DC

Image from Ethan Perlstein 1-to-N (@eperlste)

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Ethan Perlstein 1-to-N

@eperlsteNov 11

TradBio and TradAcad are slinging cope left and right over here, but this is the correct take 🎯👇

@PRVWatchNov 11

This clip has lit up BioX and I dont agree with the hate. The AI labs have the capital, let them try, they either succeed and its great for humanity or they don't and we learn far more from the billions invested in some of these diseases that we currently barely understand.

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Ethan Perlstein 1-to-N

a year’s worth of AI productivity gains wiped out by a few Jensen memes

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Ethan Perlstein 1-to-N retweeted

@internetkid69Nov 8

definition of wife changing money

Image from Internet Kid (@internetkid69)

Image from Internet Kid (@internetkid69)

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Ethan Perlstein 1-to-N retweeted

Autism Capital 🧩

@AutismCapitalNov 8

"It's actually called a Polycule. It's like a molecule but polyamorous. It's a new way of looking at things."

Image from Autism Capital 🧩 (@AutismCapital)

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Ethan Perlstein 1-to-N

only 2 possibilities: they actually like each other they’re lavender

BuccoCapital Bloke

@buccocapitalNov 8

Zuck is the last wife guy standing

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