Precigenetics

I don't think AI can cure cancer until it has the right data to learn from. Right now, that data mostly doesn't exist. I believe Precigenetics can change that. Most large biological datasets used to train AI "virtual cell" models show cells at a single moment, usually because the measurement (ex: sequencing) destroys the cell. You get a "before" and an "after" treatment, but not the path in between. That path can matter a lot though. For example, tumor cells adapt to drugs over hours and days, and resistance often emerges in exactly the window a snapshot misses. Precigenetics addresses this challenge by measuring the dynamic response of cells to drugs and other perturbations. They can measure morphological and biochemical changes inside living cells, without labels or killing the cell. The second problem is that most of this kind of data comes from 2D cell lines or animal models, which often don't represent how human tissue will respond. That's one reason so many drugs that look promising in preclinical studies fail in human trials. Precigenetics is extending its platform to human organoids, 3D tissue models that more closely resemble real human biology. Put those together and you get exactly the kind of data that is needed to train the next generation of AI virtual cells to solve cancer (and other diseases!). Parmita is a formidable founder and she is now looking for investors to support her mission. If you are an angel investor, I highly recommend reaching out! Full disclosure: I am an advisor for, and hold equity in Precigenetics.

If I had $1B I would build in noninvasive biotech devices. Microscopes. Shine some waves on your cells to understand what state they’re in at multiple time points

Please repost this for reach. We are soon going to be looking for a chief of staff (CoS) for Precigenetics!!! Email parm@precigenetics.com We will have a hiring page launch at Precigenetics dot com slash careers for other roles like -head of automation (robotics and factory scale/biomanufacturing expertise): sasaan@precigenetics.com -executive assistant, primarily for my schedule: parm@precigenetics.com -business dev lead: Pharma: parm@precigenetics.com , aru@precigenetics.com -business dev lead: AI: parm@precigenetics.com, aru@precigenetics.com -CSO (looking for professors and other people right out of the industry): parm@precigenetics.com -wet lab biologist, complex cell culture: aru@precigenetics.com, parm@precigenetics.com -biologist, toxicology (hepatotox): aru@precigenetics.com, parm@precigenetics.com You can also dm at @arubikscube , @parmita , @SasaanAShowghi , and soon will be opening DMs on @Precigenetics For any other info, email admin@precigenetics.com

Tycho is our industrialized effort. What the space is to a James Webb Space Telescope, life is to Tycho.

I'm so far into Tpot that last night I had a dream @bryan_johnson was in the hospital and being treated by @parmita who was doing some modification on his body and when she walked off they brought him a tray of food. It had peach rings and gummy worms and chicken and he started lecturing the staff on how they were serving sick people poison 😭😭😭😭 I told him I'd go grab apples but he decided not to have one because they weren't organic. Idk idk idk it might have just been a nearby reality and not a dream.

AlphaFold is a throughput optimization on drug discovery, not a latency optimization. You still need to go through phase 1/2/3 clinical trials, but the number of drugs that enter clinical trials + pass all of them increases

We are making great progress here in AZ. So excited to show you all what we are building here!