Suyash Shringarpure (@suyashss) profile picture

Suyash Shringarpure

@suyashss

Scientist at 23andMe. Interests: Machine learning, Genetics, Privacy

Joined September 2008
  • Tweets124
  • Following339
  • Followers197
3Media
Photo by Suyash Shringarpure (@suyashss)Photo by Suyash Shringarpure (@suyashss)
🧬 Just published a new blog post on reinforcement fine-tuning (RFT) for causal gene identification using Llama models! We show how a fine-tuned 8B parameter model can match the performance of a 70B model on this task. 🧵 (1/8)
1
1
6
1,040
Inspired by OpenAI's RFT demo last year, I recreated a similar setup for identifying genes causing diseases from GWAS results. With just ~600 training examples, it doubled the accuracy of Llama-8B. suyashss.github.io/llm/2025/… (2/8)

Reinforcement Fine-Tuning to Identify Causal Genes with Llama Models

Alt Title: Recreating OpenAI’s reinforcement fine-tuning demo with Llama models

suyashss.github.io
1
112
I built a tiny vision-language model using the MNIST digits dataset that can: ✅ Classify images → numbers ✅ Generate images from digit labels It combines image tokenization & nanoGPT for training.
Image from Suyash Shringarpure (@suyashss)
Image from Suyash Shringarpure (@suyashss)
1
3
185
Read more & try it out: 🔗 suyashss.github.io/vision-la…

Building a Tiny Vision-Language Model with MNIST for Classification and Image Generation

TL;DR - In this post, we will train a tiny multimodal language model, also called a vision language model (VLM), that can generate both text and images. VLMs are powerful tools for tasks like image...

suyashss.github.io
1
86
Our latest preprint - PRS can predict 1-yr incidence for 12 diseases in multiple ancestries (study of 8.5M individuals) medrxiv.org/content/10.1101/… PRS add information to conventional risk factors, and favorable lifestyle linked to lower risk in high-PRS group
3
25
1,889
New preprint - In a GWAS of cataract in Puerto Ricans, we found a rare variant association with odds ratio 12.7! Work led by Jing Shi. @jaredmoconnell @kasia_bryc @vvacic @willfreyman @NouraAbulHusn @adamauton @23andMeResearch medrxiv.org/content/10.1101/…
GWAS of cataract in Puerto Ricans identifies a novel large-effect variant in ITGA6

GWAS of cataract in Puerto Ricans identifies a novel large-effect variant in ITGA6

Cataract is a common cause of vision loss and affects millions of people worldwide. Genome-wide association studies (GWAS) and family studies of cataract have demonstrated a role for genetics in...

medrxiv.org
8
2
33
13,654
Join our webinar tomorrow 9-10 am PST to learn more about how self-reported #raredisease data can be used to discover genetic associations for rare diseases!
23andMe Research (@23andMeResearch) profile picture23andMe Research@23andMeResearch3 Dec 2021
Join us for a free webinar on our #RareDisease research Tuesday, Dec 7th from 9am - 10am PST Featuring Suyash Shringarpure PhD, Sr. Scientist II, Statistical Genetics & John Matthews, PhD, MRCP (UK), Sr. Clinical Development Fellow Register in advance: 23andme.zoom.us/webinar/regi…
Image from 23andMe Research (@23andMeResearch)
Image from 23andMe Research (@23andMeResearch)
3
2
Excited to present our work on studying rare diseases using gwas on self-reported data today Oct 19 at #ASHG21 from 4-4:15 pm ET. Link to session ashg2021.ashg.org/live-strea…
23andMe Research (@23andMeResearch) profile picture23andMe Research@23andMeResearch17 Oct 2021
Replying to @23andMeResearch
On Tuesday at #ASHG21 23andMe's @suyashss will give a talk: “Novel genetic associations for rare diseases with GWAS and trans-ethnic analysis of self-reported medical data” Suyash Shringarpure, PhD, Sr. Scientist I, Statistical Genetics Tue, Oct 19; 4:00pm - 4:15pm ET
7
2
13
Excited to share our new preprint on studying #RareDisease with self-reported diagnosis data and GWAS, where we show this approach can recover known genetic associations for rare diseases and also discover new associations medrxiv.org/content/10.1101/…
Large-scale trans-ethnic replication and discovery of genetic associations for rare diseases with...

Large-scale trans-ethnic replication and discovery of genetic associations for rare diseases with...

A key challenge in the study of rare disease genetics is assembling large case cohorts for well-powered studies. We demonstrate the use of self-reported diagnosis data to study rare diseases at...

medrxiv.org
1
16
1
43
Some awesome uses of the ipad! http://vimeo.com/11886557
iPad + Velcro

iPad + Velcro

Two of mankind's greatest inventions, together at last. Note: this is an exploration of what is possible, not necessarily what is practical. Tweet from the street at your own risk! http://jesserost...

vimeo.com
Likes Lucid Lynx!
Raag Bhairavi = Dhoom machale dhoom! http://goo.gl/JFg1
The Morality of Murder | Harvard Political Science Lecture http://bit.ly/3FweGF
Floods in Pittsburgh?!!!
A Trailer for Every Academy Award Winning Movie Ever - Funny Videos | Cracked.com http://bit.ly/bBM9AA
And they thought Almunia was bad!! #arsenal
Tautology club: http://xkcd.com/703/
Honor Societies

Honor Societies

xkcd.com
Snow day 2!
is that game over? #superbowl
Snow, and lots of it! http://bit.ly/bae0FQ
Arsenal 1 - Man United 3. No surprises there.
Cricinfo on the kindness of the Aussies to Pakistan " Australia inflicted a crushing 135-run victory in Perth" ?!!
Load more