Scientist at 23andMe. Interests: Machine learning, Genetics, Privacy
Joined September 2008
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Suyash Shringarpure retweeted
Delighted to share our latest research from the @23andMeResearch Team, just published in @Nature
! We looked at data from >27,000 participants to uncover how human genetics influences weight loss efficacy and side effects of GLP-1 medications like semaglutide. A thread 🧵👇
Suyash Shringarpure retweeted
Delighted to see our method, PRSformer, at #NeurIPS2025! PRSformer is AI model for population-scale disease-risk prediction from individual genomes. It lays the groundwork for phenome-wide risk prediction. biorxiv.org/content/10.1101/…
Suyash Shringarpure retweeted
🚨New work led by #CZBiohubCHI Investigator Aly Khan & @23andMeResearch accepted to #NeurIPS2025. PRSformer: disease risk prediction from genetic variants at population scale! New scaling law (N>1M) + multitask + multi-ancestry gains for 18 immune traits.
biorxiv.org/content/10.1101/…
imho, GSM8k is not a proper RL demo task for these papers.
i propose the Sudoku task that @HrishbhDalal wrote a GRPO blogpost about.
it's not the same style of data that the Qwen team annealed on,
and it only works at ~7b+ scale (this applies to most complex RL tasks for LLMs)
Similar experience trying gene ranking with RL like in the OpenAI demo. I found that 8b models work well, but smaller models need multiple rewards that can be hacked, and don’t do so well. suyashss.github.io/llm/2025/…
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🧬 Just published a new blog post on reinforcement fine-tuning (RFT) for causal gene identification using Llama models! We show how a fine-tuned 8B parameter model can match the performance of a 70B model on this task. 🧵 (1/8)
More tagging typos: Thanks to @charles_irl
for the @modal_labs credits, and @HamelHusain and
@dan_s_becker for their LLM fine-tuning course.
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I built a tiny vision-language model using the MNIST digits dataset that can:
✅ Classify images → numbers
✅ Generate images from digit labels
It combines image tokenization & nanoGPT for training.
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Read more & try it out: 🔗 suyashss.github.io/vision-la…
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Suyash Shringarpure retweeted
The genetic architecture of gene expression in individuals of African and European ancestry medrxiv.org/cgi/content/shor… #medRxiv
Suyash Shringarpure retweeted
📌Publication alert: In a preprint from the @23andMeResearch team, we conducted one of the largest GWAS study of Long COVID and identified genetic links of chronic conditions with Long COVID.
medrxiv.org/content/10.1101/…
