Decoding Female Bio @athenabiorg & Omaxxing since 2022. All typos and ESL are mine.
Joined February 2009
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The AIxBIO predictions are accelerating.
(Even though I was just told it might be too ambitious to get endpoints or biomarkers on a 5 year period for ovarian aging.)
So I went to my favorite drug discovery expert Jack Scannell @eroomslaw to get insights.
Our must read interview here:
Can AI truly revolutionize drug discovery when many of the diseases we're trying to treat remain poorly understood?
Today we published our technical brief on @github and an AIxBIO interview, with drug hunter the father of “Eroom’s Law” Jack Scannell @eroomslaw.
It references the recent @nature paper he co-authored: “Artificial Intelligence in Drug Discovery: “What It Is, Where We Stand and the Path Forward.”
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In my humble opinion these pronouncements are getting tiring.
While some will get extremely wealthy but we still have Alzheimer’s, ALS, cancer and everything in between, who will be held accountable for not delivering?
You cannot master what you do not know, and there is a lot of biology, we simply don’t know.
I get it, hype sells, I get it, investors hear ex-frontier lab employee and they want to throw capital at you. I also do believe AI will accelerate progress but I think many are greatly underestimating what nature built in thousands of years of evolution.
I was really looking forwards to attending @foresightinst Vision Weekend. All the VWs, this felt like the one not to miss.
I become a Fellow in 2022 thanks to @allisondman. It would have been amazing to be there before she moves on to another role.
The lineup looks stellar.
Alas medical emergencies will do that to you, and this is why we need more progress to keep us healthy asap!
A sold-out Vision Weekend returns this week to San Francisco!
Expect our main 40th anniversary celebration in the US, expert talks across seven tracks, a $10K idea competition, sci-fi book swap, behind-the-scenes lab tours, and more.
This year also includes a Founder & Funder Mixer, this Sunday at Lighthaven: a curated evening for founders, researchers and investors working on secure AI, nanotech, neurotech, space and energy, and longevity biotech.
Still looking for a ticket? Sign up to our waiting list.
Links in replies.
Vision Weekend USA is powered by @protocollabs, @eigenlabs, @paradromics, @RetroBio_ , FUTO, @d_model_ai, and @Convergent_FROs.
Hey world, Jack Scannell is back after getting locked of his account with a new handle @eroomslaw
If you care about drug discovery, give it a follow!
“Imagine inventing a car, attaching it to a horse, and proudly announcing that you’ve revolutionized transportation. The horse is still doing most of the work, the carriage looks suspiciously familiar, and the only meaningful innovation is a very expensive steering wheel, powered by a computer. Welcome to a surprisingly large portion of the AI drug discovery industry.” @dshlos
It seems SF billionaires are obsessed with magazines and publishing in print.
I hope everyone has a subscription to Cabana!
It’s the ultimate in aesthetic and taste, and “one of the world’s most luxurious interior’s magazine”.
Martina Mondadori is an arbiter of chic and class for in-the-know class.
She is also Ashley Hick’s partner who is Lord Mountbatten grandchild and Prince Phillip’s godson and a well known interior designer himself.
Random tidbit: Ashley had “society's first ever Instagram wedding” with a friend of mine, Kata de Solis. It all ended in divorce when he left her for her friend, Martina.
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I used to think Mossad were the best in intelligence but clearly the Ministry of State Security (MSS), also known in Chinese as Guójiā Ānquán Bù (国家安全部 are showing they got game.
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Insanely true
Ok I’m further into Citizen Kim. One under discussed aspect of the kardashians is how they live in a kind of feudal family estate arrangement in giant houses all within at most a 15 min drive of each other (many are walkable) so their kids can all be incredibly close. The men in their lives are barely important to the overall arrangement, they come, they go, they’re not part of the structure Kris Jenner has created. They seem kind of broadly hated by feminists but in a weird way they’ve created the ultimate feminist utopia, at least as it can exist under capitalism. They’re completely financially free from men, in fact any man that even wanders into the picture is often dependent on them, and their kids are raised in a kind of sisterly hive mom way. I think because they’re hot or at least dress to appeal to the male gaze this aspect of their whole thing is never discussed but it’s kinda radical. They’re essentially “post men.”
I think a lot about this. Women did not use the pill will go on HRT (hormone replacement therapy) because it is the only option to mitigate the symptoms of menopause.
I heard of someone going on it at 38.
That’s a good potentially over 2 decades of hormones treatment.
Who has studied this?
As Hormone Use Increases, Some Doctors Warn Slight Cancer Risk Is Being Overlooked nytimes.com/2026/11/06/well/… via @NYTimes
The biggest thing I learned about my ongoing home renovation is that I made a lot of wrong assumptions.
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This
.@dawallach explains why the success of GLP-1s, which took decades to develop inside big pharma rather than a startup, shows just how difficult it is to turn drug ideas into treatments, even with AI:
D.A.: "The bottleneck is not ideas... The challenge right now, even before AI, was that we have a superabundance of good ideas for new drugs. You can go look at any university in America or now in China and Europe. Great science everywhere."
John: "Every time a new blockbuster drug comes out, I do the research on where it came from and it's like a guy invented it in the '80s and then it was used for some really small thing in the '90s, and then they finally got it to scale in the 2010s."
D.A.: "The GLPs are one of those stories. It's kind of an indictment of the startup ecosystem. That didn't come from a startup. The story in big pharma has been all the new drugs come from M&A.
But the GLPs are the biggest, and they didn't. They were like a 20-year project inside of big pharma.
AI, from the standpoint of a big pharma company, is going to chip away in incremental ways at a million different things... Maybe a drug's development time goes from 12 years to 11 years and then maybe to 10 years... But is it going to cure cancer overnight? Is it going to solve aging overnight? Those are sales pitches."
It’s crazy that Alicia Jackson of ARPA-H is on administration leave over “maybe” supporting the removal of the black box label on HRT and because she kept $115 000 of stock options on the company she funded.
They always make examples of women.
Always.
The scariest part is what that a lot of this is being advertised on IG and probably on TikTok with zero guardrails.
My head spins when I see what’s being offered or the claims that are being made.
This reminded of a @kaimicahmills quote I am paraphrasing.
“We will achieve longevity but it won’t be pretty.”
If they dared, biohacking bros who seek to defy aging could try a simple, time-tested method: castration.
Removing the testicles extends male life span across many mammalian species, including humans. But a research team exploring this effect has now found the surgical procedure doesn’t have to be performed early in life to boost longevity, as scientists had assumed.
In a new preprint, the group reports that neutering older male mice lengthens their lives by more than 30%, upending prevailing ideas of how the testes influence aging.
Learn more: scim.ag/4eMYMV1
ALT Castration extends life span, but in a surprising way, mouse study suggests
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I am trying to share a document to ovarian researcher David Pepin but longevity researcher @davidasinclair ’s email keeps indexing.
They are both at Harvard, and the document is about reproductive longevity. Is the universe telling me something?
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