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Earl K. Miller

@MillerLabMIT

Picower Professor of Neuroscience at MIT https://xitter.twitterapi.xyz/t.co/UoEeD2FzEY Co-founder, Neuroblox https://xitter.twitterapi.xyz/t.co/o6wosMSGen

 Cambridge, MA
ekmillerlab.mit.edu/
Joined May 2011
  • Tweets11.2K
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Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)
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Miller Lab at the 2026 Society for Neuroscience meeting. Come by and say hi. #SfN2026
Image from Earl K. Miller (@MillerLabMIT)
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Replying to @VFD_org @StuartHameroff
Whatever is unifying consciousness also must be organizing it Thoughts are organized – at Somerville, MA
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Data Colada turns up more evidence of fraud by Gino. Cheaters tend to be serial offenders. datacolada.org/141
[141] Data Falsificada #5: Fold Me Once…

[141] Data Falsificada #5: Fold Me Once…

In 2023, we wrote a series of posts describing evidence of fraud in four articles co-authored by Harvard professor Francesca Gino. The four papers were retracted and, after Harvard conducted a leng…

datacolada.org
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Replying to @StuartHameroff
To me, it suggests that low-dimensional manifolds act on multifunctional (mixed-selectivity) neurons to route information at the mesoscale. I agree about the distribution but a holographic model lacks the organizational mechanisms needed for coherent, goal-directed thought.
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Shared fluctuations in neural activity mark which information the brain passes along, allowing the same circuit or brain area to serve different purposes. This is consistent with the widespread mixed selectivity observed in cortex. doi.org/10.1073/pnas.2523217… #neuroscience
The structure of correlated variability reflects task-relevant information in sensory neurons | PNAS

The structure of correlated variability reflects task-relevant information in sensory neurons | PNAS

Shared trial-to-trial variability across sensory neurons is reliably reduced when perceptual performance improves, yet this variability is low dime...

pnas.org
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When monkeys “count out” a number of actions, they seem to decide when to stop the same way brains make other decisions. Evidence builds up step by step until it hits a threshold. doi.org/10.1073/pnas.2620933… #neuroscience
The decision to stop “counting” explains numerical underproduction in primates | PNAS

The decision to stop “counting” explains numerical underproduction in primates | PNAS

Sequential numerical production requires generating a target number of actions, but the mechanisms governing the termination of counting sequences ...

pnas.org
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Replying to @joxjeff @CVakalopoulos @StuartHameroff
Thanks. Also see work by Nicholas Schiff. Thalamic stimulation on minimally conscious patients partially restores consciousness.
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Replying to @CVakalopoulos @joxjeff @StuartHameroff
I don’t follow the logic. Thalamic nuclei differ. Evidence that one isn’t involved doesn’t rule out others. Medial thalamic stimulation “awakened” anesthetized NHPs and reversed the electrophysiological features of unconsciousness. doi.org/10.7554/eLife.60824
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

Understanding how general anesthesia changes neural dynamics in the cortex and thalamus can lead to its safer use and shed light on the nature of consciousness.

elifesciences.org
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Replying to @joxjeff @StuartHameroff
I go with evidence. Even the most beautiful theory lives and dies with evidence. – at Somerville, MA
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Replying to @StuartHameroff
ILN damage can produce minimally conscious states, not just locked-in syndrome. This and other evidence point to a central role for the thalamus, including that thalamic stimulation can restore consciousness in minimally conscious patients and reverse anesthetic effects.
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The Earl K. Miller First Generation Scholarship helps first-generation college students who face financial barriers. You too can support these students by making a gift. kent.edu/alumni-and-giving
Alumni and Giving

Alumni and Giving

kent.edu
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Replying to @Williamjoyful @StuartHameroff
Yes, indeed. And damage to the ILN of the thalamus causes coma.
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This project is the result of the continued awesome work of @MatthewBroscha1
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Replying to @StuartHameroff
High-frequency thalamic stimulation restored consciousness in subjects under deep propofol anesthesia. Something is going through it. doi.org/10.7554/eLife.60824
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

Understanding how general anesthesia changes neural dynamics in the cortex and thalamus can lead to its safer use and shed light on the nature of consciousness.

elifesciences.org
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This project is the result of the continued awesome work of @MatthewBroscha1
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Timely, far-reaching theta waves help organize cognition, study shows picower.mit.edu/news/timely-… #neuroscience – at Cambridge, MA
Timely, far-reaching theta waves help organize cognition, study shows

Timely, far-reaching theta waves help organize cognition, study shows

When MIT neuroscientists measured brain cell activity and brain waves during a categorization game, they found that “theta” frequency waves dynamically sculpted multiple processes associated with...

picower.mit.edu
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Brain Biomarkers Brain disorders are notoriously mysterious. To improve diagnosis and to better measure treatment efficacy, Picower Institute labs are developing objective and minimally invasive indicators of brain health. picower.mit.edu/news/brain-b… @MIT_Picower
Brain Biomarkers

Brain Biomarkers

Brain disorders are notoriously mysterious. To improve diagnosis and to better measure treatment efficacy, Picower Institute labs are developing objective and minimally invasive indicators of brain...

picower.mit.edu
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19-45 Hz rhythm in the central thalamus looks like a signature of “conscious-like” brain states (awake and dreaming) as opposed to unconscious ones. Thalamic oscillations distinguish natural states of consciousness in humans nature.com/articles/s41562-0… #neuroscience
Thalamic oscillations distinguish natural states of consciousness in humans

Thalamic oscillations distinguish natural states of consciousness in humans

Nature Human Behaviour - Chowdhury et al. report the discovery of a 19–45-Hz thalamic oscillation that is present during human wakefulness and REM sleep, but not NREM sleep.

nature.com
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Earl K. Miller retweeted
Felix Scholkmann (@FScholkmann) profile picture
Felix Scholkmann@FScholkmannNov 9
Direct human central thalamus recordings have identified a 19-45 Hz oscillation specific to conscious states (Chowdhury et al., 2026, nature.com/articles/s41562-0…). Theories of the neural correlates of consciousness need to consider the thalamus.
Image from Felix Scholkmann (@FScholkmann)
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So recursive
Michael Platt (@MichaelLouisPl1) profile pictureMichael Platt
@MichaelLouisPl1Nov 7
Kumbayaaaaaaaaaaaa
Image from Michael Platt (@MichaelLouisPl1)
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