Earl K. Miller (@MillerLabMIT) header
Earl K. Miller (@MillerLabMIT) profile picture

Picower Professor of Neuroscience at MIT https://xitter.twitterapi.xyz/t.co/UoEeD2FzEY Co-founder, Neuroblox https://xitter.twitterapi.xyz/t.co/o6wosMSGen

Cambridge, MA
Joined May 2011
Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)Photo by Earl K. Miller (@MillerLabMIT)
Earl raises the key issue: distribution alone doesn't explain selection. Could phase alignment, geometric constraints and energy-dependent stability organise the low-dimensional manifolds that route neural information? Microtubules may provide local structure, but the cross-scale mechanism needs testing.
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Whatever is unifying consciousness also must be organizing it Thoughts are organized – at Somerville, MA
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Shared fluctuations in neural activity mark which information the brain passes along, allowing the same circuit or brain area to serve different purposes. This is consistent with the widespread mixed selectivity observed in cortex. doi.org/10.1073/pnas.2523217… #neuroscience
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Replying to @StuartHameroff
@StuartHameroff @MillerLabMIT you two are arguing about different jobs, and both can be true. Stu puts experience in microtubules. Earl says the central thalamus is the on switch. Stimulating it woke macaques under propofol, and strokes in the middle of both thalami caused coma. The way I see it, the thalamus is a control gate. It decides whether the cortex runs. That says nothing about what's held once it runs, which is where Stu's claim lives. Microtubule drugs made mice more sensitive to anesthetic, so microtubules matter, but that doesn't show how, and it isn't proof of collapse. The same gate shows up in other fields. A power grid control room doesn't make your light, but it decides which neighborhoods get power. An air traffic tower doesn't fly planes, but it gates who lands and when. A cell's nuclear pores decide which molecules get in and out of the nucleus. Spillway gates on a dam like Hoover, or a beaver patching its dam, set what flows and when. An octopus's central brain coordinates eight arms that can each act partly on their own. My read, still a candidate, is that the gate isn't the payer or the collector. It's the valve between them, deciding who gets paid. Sources. Redinbaugh 2020, Bastos 2021, Castaigne 1981, Li 2025, nuclear pore review PMC8789946, octopus control review Frontiers in Robotics and AI 2022, and the thread by @StuartHameroff and @MillerLabMIT
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Agreed, and your propofol work shows it best. A pulvinar lesion sparing simple vision only tells us that site isn't the wake switch. It still breaks choice and attention. Central thalamic stimulation woke the monkeys and brought the cortex's awake patterns back, so a different site carries that load. It only held while the current ran, which is the bill being paid. That's the point I made to Costa. The switch is local, but the bill it turns on is brain wide. Sources: Bastos et al. 2021, eLife 10 e60824
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Thanks. Also see work by Nicholas Schiff. Thalamic stimulation on minimally conscious patients partially restores consciousness.
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The pulvinar has been lesioned in monkey studies with little effect on visual performance. You need good theory to understand effects not just occasional findings, I would expect that stimulation of thalamus in many cases doesn’t arouse
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I don’t follow the logic. Thalamic nuclei differ. Evidence that one isn’t involved doesn’t rule out others. Medial thalamic stimulation “awakened” anesthetized NHPs and reversed the electrophysiological features of unconsciousness. doi.org/10.7554/eLife.60824
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I go with evidence. Even the most beautiful theory lives and dies with evidence. – at Somerville, MA
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Lesions to thalamus can cause or contribute to ‘locked in syndromes’ in which the subject remains conscious but doesn’t perceive or communicate, That alone proves thalamus isn’t necessary for consciousness,
Yes, indeed. And damage to the ILN of the thalamus causes coma.
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ILN damage can produce minimally conscious states, not just locked-in syndrome. This and other evidence point to a central role for the thalamus, including that thalamic stimulation can restore consciousness in minimally conscious patients and reverse anesthetic effects.
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The Earl K. Miller First Generation Scholarship helps first-generation college students who face financial barriers. You too can support these students by making a gift. kent.edu/alumni-and-giving
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Conscious smell/olfaction doesn’t go through thalamus, so thalamus can’t be necessary for consciousness. Microtubules are necessary for consciousness.
19-45 Hz rhythm in the central thalamus looks like a signature of “conscious-like” brain states (awake and dreaming) as opposed to unconscious ones. Thalamic oscillations distinguish natural states of consciousness in humans nature.com/articles/s41562-0… #neuroscience
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Yes, indeed. And damage to the ILN of the thalamus causes coma.
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New paper! Theta as a master clock. It couples to relevant spiking, direct information flow and has nested cross-frequency interactions with beta and gamma oscillations. Theta-based organization of information in the frontal cortex sciencedirect.com/science/ar… #neuroscience
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This project is the result of the continued awesome work of @MatthewBroscha1
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Brain Biomarkers Brain disorders are notoriously mysterious. To improve diagnosis and to better measure treatment efficacy, Picower Institute labs are developing objective and minimally invasive indicators of brain health. picower.mit.edu/news/brain-b… @MIT_Picower
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19-45 Hz rhythm in the central thalamus looks like a signature of “conscious-like” brain states (awake and dreaming) as opposed to unconscious ones. Thalamic oscillations distinguish natural states of consciousness in humans nature.com/articles/s41562-0… #neuroscience
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Earl K. Miller retweeted
Direct human central thalamus recordings have identified a 19-45 Hz oscillation specific to conscious states (Chowdhury et al., 2026, nature.com/articles/s41562-0…). Theories of the neural correlates of consciousness need to consider the thalamus.
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Earl K. Miller retweeted
WMBR 88.1 FM in Cambridge is putting our new single, Perceptual Echo, in rotation. But you don't have to wait. You can listen now. generalbonkers.bandcamp.com/… Each part echoes another, like the waves of perceptual echoes that reverberate around the brain after sensory input.
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