Posts are my own immediate personal reflections on current events or views expressed by others. Retired. Professor, Translational and Functional Genomics.
La Jolla, CA
Joined July 2015
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Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Getting it wrong for many decades.
Since the 1950's, pacemaker leads have been placed in the right ventricle. A new randomized trial challenging that dogma found marked superiority of outcomes for pacing from the left bundle branch. nejm.org/doi/full/10.1056/NE…
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Notable: Researchers from 50 institutions collaborate to find a biomarker that has the potential to detect ovarian cancer very early, even pre-malignant
A cancer not detected by the Galleri test.
An extracellular vesicle long non-coding RNA
@NatureMedicine
nature.com/articles/s41591-0…
nature.com/articles/s41591-0…
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
"Simply Aging"
A brilliant perspective on the complex (anything but simple) biology of human aging, by @VadimGladyshev @gladyshev_lab open-access @PNASNews pnas.org/doi/10.1073/pnas.26…
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Your heart, brain, and immune system share the same DNA sequence. So how can a single-letter change affect disease in some cells, while sparing the rest?
AlphaGenome 2 is our new AI model that zooms in on specific cells to help scientists understand what drives disease. 🧵
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Super proud to announce AlphaGenome 2 - our new DNA sequence model! 🧬 It predicts the impact of DNA variants in different specific cell types - unlocking crucial information for understanding complex diseases. Available for academic research via our API: alphagenomedocs.com/
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Here's my conversation all about the state of the war in Ukraine with Preston Stewart (@prestonstew_) and Michael Kofman (@KofmanMichael).
It's here on X in full and is up everywhere else (see comment).
Timestamps:
0:00 - Introduction
1:00 - State of the war in Ukraine
14:39 - Drone warfare and the kill zone
51:49 - Who is winning the war?
1:03:26 - Military analysis of Russia's 2022 invasion
1:19:14 - Battle of Bakhmut
1:34:56 - War optimism and bad information
1:55:05 - Prigozhin's mutiny
2:09:20 - Putin vs Zelenskyy
2:27:18 - Trump
2:36:13 - Paths to peace in Ukraine
2:46:53 - Nature of war
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Should patients pay $1,000 for a full-body MRI scan? New @NEJMClinician Editor-in-Chief @PaulSaxMD, weighs the benefits and harms.
See what else matters this week at clinician.nejm.org, including:
❤️ Anticoagulation for Patients with Atrial Fibrillation and One Risk Factor
🩺 Improving Management of Resistant Hypertension
☕ Coffee Consumption and the Liver
🥛 Unpasteurized Milk: Still a Raw Deal
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Ocean waters off San Diego County are nearly as warm as those off Cape Canaveral, Florida, at 75°F (24°C).
That's nearly 11°F (6°C) above normal, instead of the rapid cooling November usually brings.
El Niño is the main culprit.
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
This is f*cking insane. Elon Musk just said Grok 5 will beat Opus 5.5 in 2 to 3 months. This is how his senior engineer already works with Grok Bot:
"You spend the tokens once to set up the codebase, so even the dumbest agent does a good job
Then you stop babysitting. 200+ agents, and I don't check a single one"
In this 55-minute workshop, she shows why the setup matters more than the number of bots
Job → Rules → Skills → Verification → 6 Bots → 200+ Agents
Most people add another bot when the first one fails. That just multiplies the mistakes
Worth more than most $2,000 agent engineering courses
Bookmark and watch it today
Then read what one person runs on that setup: 6 Grok bots, 200+ agents ↓
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
California is experiencing one of the most extraordinary marine heatwaves in it's history. Water temperatures off Santa Barbara reached nearly 75°F today, 12°F above normal. Off San Diego County, temperatures reached above 77°F in the past week.
From the Bay Area to San Diego, coastal waters are running 6–12°F above normal. Category 5, or “beyond extreme,” marine heatwave conditions are occurring along virtually the entire Southern California coast.
Farther north, temperatures off Monterey have reached 68°F and 67°F off Half Moon Bay.
This exceptional warmth could have major consequences for marine life and could help enhance storms this winter.
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
😳 Tokyo subway during rush hour is an extreme sport of its own
A video making the rounds on social media shows passengers desperately trying to squeeze into an already packed train.
But the real star is a man in a suit standing calmly by the doors. Apparently, he's figured out the golden rule of Tokyo's subway: why bother getting on the train yourself when everyone else will push you in?
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
When Italians sing in French 🇮🇹🇫🇷
Giulia Falcone | La Vie en Rose 🌹
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
President Trump sat down with Ross Douthat in November 2026 to discuss Republican losses in the midterm elections, the wars in Iran and Ukraine, the economy, and more.
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Presented at #ScientificSessions26:
In older adults with at least two chronic conditions and no known atherosclerotic cardiovascular disease, statin discontinuation was noninferior to continuation for a composite of myocardial infarction, stroke, or death at 2 years. Full STREAM trial results: nej.md/47U1X9N
@AHAScience
ALT A graph from the Original Article "Discontinuing Statins in Older Adults without Cardiovascular Disease." The trial name, STREAM, is in parentheses after the title. The graph shows estimated cumulative incidence of primary-outcome events. The trial results are being presented at the American Heart Association Scientific Sessions 2026. The logo of the New England Journal of Medicine is at the bottom.
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Presented at #ScientificSessions26:
In patients with type 2 diabetes and high cardiovascular risk, a systolic blood-pressure target below 120 mm Hg did not result in fewer major cardiovascular events than a target below 140 mm Hg. Full OPTIMAL-DIABETES trial results: nej.md/3UZYKCy
@AHAScience
ALT A graph from the Original Article "Intensive Blood-Pressure Lowering in Patients with Type 2 Diabetes.” The trial name, OPTIMAL-DIABETES, is in parentheses after the title. The graph shows Kaplan–Meier curves for the primary outcome. The trial results are being presented at the American Heart Association Scientific Sessions 2026. The logo of the New England Journal of Medicine is at the bottom.
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
We are at the beginning of a new and exciting era to be able to program our immune system in the body (in vivo). This new review @SciImmunology nails it science.org/doi/10.1126/scii…
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Nature research paper: Transcriptomic convergence and the female protective effect in autism
go.nature.com/3UkDK9r
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
One-and-done lipid-lowering therapies are moving closer to reality, slowly but surely.
These are new data just published in Nature: we know that PCSK9 is a good target here, but this study tests ANGPTL3, which regulates both LDL cholesterol and triglycerides.
This tech is from Verve (now Lilly) -- their base editor safely lowered ANGPTL3, LDL cholesterol and triglycerides, in mice and primates.
This clinical trial has already started.
Paper here: nature.com/articles/s41586-0…
Dr. Gennadi Glinsky, MD, Ph.D. retweeted
Nature research paper: A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity
go.nature.com/4kwQHr8
